Growth differentiation factor 11 (GDF11) has pronounced effects on skin biology

Autor: Jolanta Idkowiak-Baldys, Sean M. Buchanan, Kathleen L. Pfaff, Lee L. Rubin, John W. Lyga, Uma Santhanam
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Keratinocytes
Pigments
Skin Physiology
Aging
Physiology
Human skin
Myostatin
Epithelium
Skin Aging
Melanin
Mice
0302 clinical medicine
Endocrinology
Animal Cells
Medicine and Health Sciences
Materials
Skin
Connective Tissue Cells
Multidisciplinary
integumentary system
Photodermatology and Skin Aging
Middle Aged
Recombinant Proteins
Cell biology
Growth Differentiation Factors
Connective Tissue
030220 oncology & carcinogenesis
Bone Morphogenetic Proteins
Physical Sciences
Melanocytes
Medicine
Female
Anatomy
Integumentary System
Cellular Types
Research Article
Science
Primary Cell Culture
Materials Science
Dermatology
Biology
Cell Line
03 medical and health sciences
Growth Factors
Animals
Humans
Organic Pigments
Endocrine Physiology
Endothelial Cells
Biology and Life Sciences
Epithelial Cells
Cell Biology
Fibroblasts
In vitro
030104 developmental biology
Biological Tissue
GDF11
Microvessels
biology.protein
Physiological Processes
Organism Development
Ex vivo
Transforming growth factor
Developmental Biology
Zdroj: PLoS ONE, Vol 14, Iss 6, p e0218035 (2019)
PLoS ONE
ISSN: 1932-6203
Popis: Growth differentiation factor 11 (GDF11) belongs to the TGF-β superfamily of proteins and is closely related to myostatin. Recent findings show that GDF11 has rejuvenating properties with pronounced effects on the cardiovascular system, brain, skeletal muscle, and skeleton in mice. Several human studies were also conducted, some implicating decreasing levels of circulating GDF11 with age. To date, however, there have not been any reports on its role in human skin. This study examined the impact of GDF11 on human skin, specifically related to skin aging. The effect of recombinant GDF11 on the function of various skin cells was examined in human epidermal keratinocytes, dermal fibroblasts, melanocytes, dermal microvascular endothelial cells and 3D skin equivalents, as well as in ex vivo human skin explants. GDF11 had significant effects on the production of dermal matrix components in multiple skin models in vitro and ex vivo. In addition, it had a pronounced effect on expression of multiple skin related genes in full thickness 3D skin equivalents. This work, for the first time, demonstrates an important role for GDF11 in skin biology and a potential impact on skin health and aging.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje