Altitude healing effect in severe asthmatic children

Autor: Joana Vitte, Denis Charpin, S. Guibert, A. Bernard, P. Quignon, F. Faraj, A.D. Loundou, P. da Mata, J. Léonardi
Přispěvatelé: Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre de RMN à très hauts champs de Lyon (CRMN), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre La Guisane, Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants (SPMC), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service de Pneumologie-Allergologie [Hôpital de la Timone - APHM], Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)
Rok vydání: 2021
Předmět:
Pulmonary and Respiratory Medicine
Spirometry
medicine.medical_specialty
Allergy
03 medical and health sciences
0302 clinical medicine
Altitude
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Quality of life
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Internal medicine
medicine
Humans
[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology
Exhaled breath condensate
030212 general & internal medicine
Child
Peak flow meter
Children
measurement_unit
Asthma
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases
Biological markers
medicine.diagnostic_test
business.industry
Effects of high altitude on humans
medicine.disease
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Breath Tests
030228 respiratory system
Exhalation
Avoidance
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
measurement_unit.measuring_instrument
Quality of Life
business
Zdroj: Respiratory Medicine and Research
Respiratory Medicine and Research, 2021, 79, pp.100810. ⟨10.1016/j.resmer.2020.100810⟩
Respiratory Medicine and Research, Elsevier, 2021, 79, pp.100810. ⟨10.1016/j.resmer.2020.100810⟩
ISSN: 2590-0412
DOI: 10.1016/j.resmer.2020.100810
Popis: International audience; Background. - The beneficial effect of a climatic treatment in children with asthma was established quite some time ago, but the mechanism of this beneficial effect has not been fully elucidated. We investigated the role of the cytokines of the TH2 pathway, reactive oxygen species (ROS) and reactive nitrogen species (RNS) over the course of a high-altitude climatic therapy.Methods. - A group of 67 children originating from various French towns suffering from uncontrolled severe asthma was sent via their medical specialists, to the Briancon climatic area. They were monitored over the course of an entire school year. During this time, they returned home for 15 days during the Christmas holidays. At each stage, assessment of asthma control, lung function examination (peak flow meter and spirometry), and measurement of exhaled NO, ROS and RNS in exhaled breath condensate (EBC), and the level of cytokines in the plasma of the TH2 pathway were carried out.Results. - The degree of asthma control improved at high altitude and worsened upon returning home. The average value of the peak expiratory flow also improved during the first 3 months but then worsened upon returning home, while the other spirometric parameters did not change. The level of expired NO and the scores for quality of life underwent a similar change. The level of RNS and ROS in the EBC did not change significantly. Besides, a marked and statistically significant decrease in the level of IL-13 and IL-10 was noted.Conclusion. - The beneficial effect of a climatic stay of children suffering from allergic asthma at altitude appears to be linked with less allergenic stimulation.
Databáze: OpenAIRE
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