Particle Image Velocimetry Measurements of the Flow-Diverting Effects of a New Generation of the eCLIPs Implant for the Treatment of Intracranial Bifurcation Aneurysms
| Autor: | Adam Tynan, Sina G. Yazdi, Daniel Mercier, Renee Bernard, Donald R. Ricci |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Materials science
medicine.medical_treatment 0206 medical engineering 02 engineering and technology lcsh:Technology lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine Aneurysm hemodynamic particle image velocimetry Fluid dynamics medicine coil General Materials Science Embolization cardiovascular diseases Instrumentation lcsh:QH301-705.5 Bifurcation Reduction (orthopedic surgery) Fluid Flow and Transfer Processes lcsh:T Process Chemistry and Technology General Engineering flow diverter medicine.disease 020601 biomedical engineering lcsh:QC1-999 Computer Science Applications Particle image velocimetry Flow (mathematics) lcsh:Biology (General) lcsh:QD1-999 lcsh:TA1-2040 bifurcation cardiovascular system aneurysm Implant velocity reduction lcsh:Engineering (General). Civil engineering (General) 030217 neurology & neurosurgery lcsh:Physics Biomedical engineering |
| Zdroj: | Applied Sciences Volume 10 Issue 23 Applied Sciences, Vol 10, Iss 8639, p 8639 (2020) |
| ISSN: | 2076-3417 |
| DOI: | 10.3390/app10238639 |
| Popis: | Flow diverters (FDs) for the endovascular treatment of intracranial aneurysms are effective for sidewall aneurysms, but their use at a bifurcation is problematic because FDs only partially cover the aneurysm neck and impede flow into a daughter branch they are thus not employed routinely in this anatomy. eCLIPs was developed as a non-tubular implant to completely cover the neck of an aneurysm and serve as a coil retention device necessary for the adequate treatment of wide-neck bifurcation aneurysms. eCLIPs has shown some flow diversion effects in bifurcation anatomy but not equal to those exhibited by clinically accepted flow diverters in sidewall anatomy. A new generation of eCLIPs implant, the eCLIPs bifurcation flow diverter (eBFD), with higher metal coverage, was developed to achieve a similar flow diversion as a Pipeline Embolization Device (PED), a prototypical FD. Particle image velocimetry was used to capture the fluid dynamics and velocity reduction within silicone aneurysm replicas. A circulatory mimicking loop was developed to circulate the flow through the silicone models. All generations of eCLIPs implants had some flow-diverting effect, with increasing metal coverage density of the implant proportionately increasing the flow diversion effect. The eBFD, with a metal density of 35%, showed greater flow diversion than PED, with 30% metal density, for bifurcation anatomy. The eBFD showed similar reduction of flow in a bifurcation anatomy to PED in a sidewall, both sufficient to permit early thrombosis of the aneurysm. Thus, the eBFD can potentially provide sufficient flow diversion for the treatment of bifurcation aneurysms to avoid adjunctive coiling. |
| Databáze: | OpenAIRE |
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