Treatment of pyoderma gangrenosum with topical factor XIII
| Autor: | Wolfram Hoetzenecker, Emmanuella Guenova, Vanyo Mitev, Stefan Schanz, Anja Ulmer, Gerhard Fierlbeck |
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| Přispěvatelé: | University of Zurich, Hoetzenecker, Wolfram |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Prednisolone Coagulation factor XIII Wound size Anti-Inflammatory Agents 610 Medicine & health Dermatology Administration Cutaneous 2708 Dermatology medicine Humans Adverse effect Beneficial effects Factor XIII Coagulants business.industry 10177 Dermatology Clinic Middle Aged medicine.disease Pyoderma Gangrenosum Positive response Drug Therapy Combination Female business Wound healing Pyoderma gangrenosum medicine.drug |
| Zdroj: | European Journal of Dermatology. 23:653-657 |
| ISSN: | 1952-4013 1167-1122 |
| DOI: | 10.1684/ejd.2013.2147 |
| Popis: | Pyoderma gangrenosum (PG) is a severe ulcerative skin disease. Despite systemic immunosuppressive therapy, PG ulcers often progress and can develop into life-threatening conditions. In this case series, we treated 6 patients suffering from recalcitrant PG with topical coagulation factor XIII, which has been shown to exert beneficial effects on tissue regeneration and wound healing. All 6 patients showed a positive response to treatment with a marked reduction in wound size that was maintained during a 3-month follow-up period. The treatment was well tolerated with no remarkable adverse effects or complications. Topical factor XIII has potential in combination with standard immunosuppressive therapy for the treatment of PG. |
| Databáze: | OpenAIRE |
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