Local pro-inflammatory cytokine and nitric oxide responses are elevated in patients with pterygium
| Autor: | C Henchiri, Chafia Touil-Boukoffa, F. Bédiar-Boulaneb, O Laouar, Mourad Belkhelfa, Sourour Zidi, Houda Belguendouz, Oussama Medjeber |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_treatment Immunology Nitric Oxide Synthase Type II Inflammation Nitric Oxide Pterygium Nitric oxide Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine NO synthase Original Research Articles Humans Immunology and Allergy Medicine Interleukin 6 Pharmacology biology Interleukin-6 business.industry Interleukin-17 NF-kappa B Middle Aged cytokines eye diseases Interleukin-10 Interleukin 10 030104 developmental biology Cytokine Proto-Oncogene Proteins c-bcl-2 chemistry inflammation Tears 030221 ophthalmology & optometry biology.protein Female sense organs Interleukin 17 medicine.symptom business Conjunctiva |
| Zdroj: | International Journal of Immunopathology and Pharmacology |
| ISSN: | 2058-7384 |
| DOI: | 10.1177/0394632017742505 |
| Popis: | Pterygium is a common ocular surface disease observed in humans. Chronic ultraviolet (UV) exposure is extensively recognized as an aetiological factor in the pathogenesis of this disease. This hypothesis is sustained by epidemiological and histopathological data in relation to UV injured skin. Although some findings have indicated that genetic factors, anti-apoptotic and immunological mechanisms are involved in the pathogenesis of pterygium, the mechanism by which it develops remains poorly understood. In this study, we analysed the in vivo production of IL-17A, IL-6, IL-10 and nitric oxide (NO) in the tears and sera from Algerian patients. Interestingly, we observed that IL-6, IL-17A and NO production in the tears and sera of all patients was strongly associated with inflammatory infiltration, NOS2, NF-κB and Bcl2 expression in pterygia biopsies. Collectively, our results indicate a relationship between local inflammation and anti-apoptotic processes in pterygium disease, leading to both tissue damage and enhanced cellular proliferation. |
| Databáze: | OpenAIRE |
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