Interactive and noninteractive roles of histone H2B monoubiquitination and H3K36 methylation in the regulation of active gene transcription and control of plant growth and development
| Autor: | Mieke Van Lijsebettens, Pia Neyt, Wei Zhao, Wen-Hui Shen, Alexandre Berr |
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| Přispěvatelé: | AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de biologie moléculaire des plantes (IBMP), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), China Agricultural University (CAU), Ghent University [Belgium] (UGENT), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2018 |
| Předmět: |
0106 biological sciences
0301 basic medicine Transcription Genetic Physiology [SDV]Life Sciences [q-bio] Arabidopsis Plant Science Flowers 01 natural sciences Methylation Histones 03 medical and health sciences Transcription (biology) Gene Expression Regulation Plant Gene expression Histone H2B Monoubiquitination Sciences du Vivant [q-bio]/Biologie végétale Nucleotide Motifs Gene ComputingMilieux_MISCELLANEOUS 2. Zero hunger biology Arabidopsis Proteins Gene Expression Profiling Lysine Ubiquitination Gene Expression Regulation Developmental [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology biology.organism_classification Chromatin Cell biology Histone Code 030104 developmental biology Histone Mutation biology.protein 010606 plant biology & botany |
| Zdroj: | New Phytologist New Phytologist, Wiley, 2019, 221 (2), pp.1101-1116 HAL New Phytologist, Wiley, 2019, 221 (2), pp.1101-1116. ⟨10.1111/nph.15418⟩ |
| ISSN: | 1469-8137 0028-646X |
| Popis: | Covalent modifications of histones are essential to control a wide range of processes during development and adaptation to environmental changes. With the establishment of reference epigenomes, patterns of histone modifications were correlated with transcriptionally active or silenced genes. These patterns imply the need for the precise and dynamic coordination of different histone-modifying enzymes to control transcription at a given gene. Classically, the influence of these enzymes on gene expression is examined separately and their interplays rarely established. In Arabidopsis, HISTONE MONOUBIQUITINATION2 (HUB2) mediates H2B monoubiquitination (H2Bub1), whereas SET DOMAIN GROUP8 (SDG8) catalyzes H3 lysine 36 trimethylation (H3K36me3). In this work, we crossed hub2 with sdg8 mutants to elucidate their functional relationships. Despite similar phenotypic defects, sdg8 and hub2 mutations broadly affect genome transcription and plant growth and development synergistically. Also, whereas H3K4 methylation appears largely dependent on H2Bub1, H3K36me3 and H2Bub1 modifications mutually reinforce each other at some flowering time genes. In addition, SDG8 and HUB2 jointly antagonize the increase of the H3K27me3 repressive mark. Collectively, our data provide an important insight into the interplay between histone marks and highlight their interactive complexity in regulating chromatin landscape which might be necessary to fine-tune transcription and ensure plant developmental plasticity. |
| Databáze: | OpenAIRE |
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