Disposition kinetics of cefamandole during continuous ambulatory peritoneal dialysis
| Autor: | M Bliss, Michael Mayersohn, T Arnold, W. N. Jones, J Logan, Ulrich F. Michael |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Metabolic Clearance Rate medicine.medical_treatment Urology Renal function Kidney Peritoneal dialysis Peritoneal Dialysis Continuous Ambulatory Elimination rate constant Pharmacokinetics Humans Medicine Pharmacology (medical) Cefamandole Dialysis Pharmacology Volume of distribution business.industry Continuous ambulatory peritoneal dialysis Middle Aged Surgery Kinetics Infectious Diseases Kidney Failure Chronic business Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 29:649-653 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | Cefamandole disposition kinetics were examined in six male subjects with renal impairment who were undergoing continuous ambulatory peritoneal dialysis. Creatinine clearance values ranged from less than 1 to 11 ml/min. Cefamandole was given as a 1-g intravenous dose infused over 30 min. Cefamandole concentrations were determined in serum, urine, and dialysis fluid by a high-performance liquid chromatographic method. The following average parameter values were obtained (range): half-life, 6.1 h (4.6 to 9.7); systemic clearance, 21.9 ml/min (8.4 to 35.5); renal clearance, 11.5 ml/min (0.03 to 22.3); dialysis clearance, 0.92 ml/min (0.7 to 1.3); nonrenal clearance, 12.2 ml/min (2.9 to 27.0); volume of distribution, 0.18 liter/kg (0.09 to 0.25); steady-state volume of distribution, 0.17 liter/kg (0.09 to 0.24). Approximately 5% of the dose was dialyzed (range, 2.8 to 8.3), indicating that there is no need to supplement a dosing regimen of cefamandole due to loss by dialysis. There was a positive correlation between creatinine clearance and the terminal elimination rate constant of cefamandole (r2 = 0.41) and cefamandole renal clearance (r2 = 0.83). |
| Databáze: | OpenAIRE |
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