Simultaneous Venoarterial Extracorporeal Membrane Oxygenation and Percutaneous Left Ventricular Decompression Therapy with Impella Is Associated with Improved Outcomes in Refractory Cardiogenic Shock
| Autor: | Guilherme H. Oliveira, Hiram G. Bezerra, Jerry Lipinski, Thomas Ladas, Marco A. Costa, Fahd Nadeem, Sandeep M. Patel, Sadeer G. Al-Kindi, Toral R. Patel, Benjamin Medalion, Basar Sareyyupoglu, Yakov Elgudin, Amer Alaiti, Ann Phillips, Salil V. Deo, Guilherme F. Attizzani, Petar Saric, Jun Li, Mohammed Najeeb Osman |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Inotrope medicine.medical_specialty medicine.medical_treatment Shock Cardiogenic Biomedical Engineering Biophysics Bioengineering 030204 cardiovascular system & hematology Biomaterials 03 medical and health sciences Extracorporeal Membrane Oxygenation 0302 clinical medicine Internal medicine medicine Extracorporeal membrane oxygenation Humans Myocardial infarction Impella Aged Retrospective Studies business.industry Cardiogenic shock Percutaneous coronary intervention Retrospective cohort study General Medicine Middle Aged medicine.disease Combined Modality Therapy surgical procedures operative 030228 respiratory system Shock (circulatory) Cardiology Female Heart-Assist Devices medicine.symptom business |
| Zdroj: | ASAIO Journal. 65:21-28 |
| ISSN: | 1058-2916 |
| Popis: | Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has been used for refractory cardiogenic shock; however, it is associated with increased left ventricular afterload. Outcomes associated with the combination of a percutaneous left ventricular assist device (Impella) and VA-ECMO remains largely unknown. We retrospectively reviewed patients treated for refractory cardiogenic shock with VA-ECMO (2014-2016). The primary outcome was all-cause mortality within 30 days of VA-ECMO implantation. Secondary outcomes included duration of support, stroke, major bleeding, hemolysis, inotropic score, and cardiac recovery. Outcomes were compared between the VA-ECMO cohort and VA-ECMO + Impella (ECPELLA cohort). Sixty-six patients were identified: 36 VA-ECMO and 30 ECPELLA. Fifty-eight percent of VA-ECMO patients (n = 21) had surgical venting, as compared to 100% of the ECPELLA cohort (n = 30) which had Impella (±surgical vent). Both cohorts demonstrated relatively similar baseline characteristics except for higher incidence of ST-elevation myocardial infarction (STEMI) and percutaneous coronary intervention (PCI) in the ECPELLA cohort. Thirty-day all-cause mortality was significantly lower in the ECPELLA cohort (57% vs. 78%; hazard ratio [HR] 0.51 [0.28-0.94], log rank p = 0.02), and this difference remained intact after correcting for STEMI and PCI. No difference between secondary outcomes was observed, except for the inotrope score which was greater in VA-ECMO group by day 2 (11 vs. 0; p = 0.001). In the largest US-based retrospective study, the addition of Impella to VA-ECMO for patients with refractory cardiogenic shock was associated with lower all-cause 30 day mortality, lower inotrope use, and comparable safety profiles as compared with VA-ECMO alone. |
| Databáze: | OpenAIRE |
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