A specific and rapid receptor assay for squamous-cell carcinoma of human esophagus
| Autor: | J. S. Nadkarni, J. J. Nadkarni, G. T. Panse |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pathology Esophageal Neoplasms medicine.drug_class Receptors Cell Surface Adenocarcinoma Biology Monoclonal antibody Sensitivity and Specificity Radioligand Assay Internal medicine medicine Carcinoma Humans Basal cell Esophagus Receptor Aged Scatchard plot Hematology General Medicine Middle Aged medicine.disease Molecular biology Kinetics medicine.anatomical_structure Oncology Carcinoma Squamous Cell Female |
| Zdroj: | Journal of Cancer Research and Clinical Oncology. 119:734-736 |
| ISSN: | 1432-1335 0171-5216 |
| DOI: | 10.1007/bf01195345 |
| Popis: | A specific radioreceptor assay, for squamous-cell carcinoma of the human esophagus, using 2G3 monoclonal antibody, has been developed for the first time. In this assay a new mathematical parameter of the Scatchard plot has been introduced for the correct measure of binding capacity (BCcm = x cos alpha). This is the perpendicular distance from the origin to the Scatchard plot line. It is always a positive quantity and is directly proportional to both the x and y intercepts for expressing the binding capacity. The assay is highly sensitive and can be used to differentiate various types of esophageal tumors such as squamous-cell carcinoma, adenocarcinoma, ulcerative growth and also a benign growth. BCcm significantly varies in the case of squamous-cell carcinoma tumors compared to adenocarcinoma and other types of tumor of the human esophagus. The assay can be completed in about 4 h and it may be used as a clinical diagnostic test. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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