Central losartan administration increases cardiac workload during aerobic exercise
| Autor: | Cândido C. Coimbra, Washington Pires, Henrique Pereira Santiago, Daniel Carvalho de Lima, Laura Hora Rios Leite |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Diastole Blood Pressure 030209 endocrinology & metabolism Losartan 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Endocrinology Heart Rate Physical Conditioning Animal Internal medicine Heart rate medicine Animals Aerobic exercise Rats Wistar Treadmill Endocrine and Autonomic Systems business.industry General Medicine Angiotensin II Rats Blood pressure Rate pressure product Neurology cardiovascular system Cardiology business Angiotensin II Type 1 Receptor Blockers 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuropeptides. 77:101960 |
| ISSN: | 0143-4179 |
| DOI: | 10.1016/j.npep.2019.101960 |
| Popis: | To assess the effects of central administration of losartan, an antagonist of angiotensin II AT1 receptors, on cardiovascular function during aerobic exercise, heart rate, systolic and diastolic arterial pressures and rate pressure product of Wistar rats were measured as cardiac workload indexes. The animals ran on a treadmill until fatigue after an intracerebroventricular injection of losartan or saline. Pulsatile arterial pressure was recorded by a catheter implanted into the ascending aorta, from which were derived cardiovascular parameters to estimate the cardiac workload. Total exercise time and exercise workload were determined as performance indexes. The rats showed a more intense increase in heart rate after 8 min of exercise and sustained until fatigue (P |
| Databáze: | OpenAIRE |
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