Palmitoyl-CoA inhibits the mitochondrial inner membrane anion-conducting channel
| Autor: | A.G. Murray, Michael J. Selwyn, S.C. Halle-Smith |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Anions
Anion channel Biophysics Mitochondria Liver Palmitic Acids Mitochondrion Biochemistry Ion Channels Palmitic acid chemistry.chemical_compound Structural Biology Palmitoyl-CoA Ribose Genetics medicine Animals Inner membrane Carnitine Inner mitochondrial membrane Molecular Biology Cells Cultured Dose-Response Relationship Drug Palmitoyl Coenzyme A Thiocyanate Chemistry Palmitoylcarnitine Rats Inbred Strains Thermogenesis Intracellular Membranes Cell Biology Inner membrane anion-conducting channel Hydrogen-Ion Concentration Mitochondrial inner membrane Culture Media Rats lipids (amino acids peptides and proteins) Acyl Coenzyme A medicine.drug |
| Zdroj: | FEBS Letters. (1):155-158 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/0014-5793(88)80305-3 |
| Popis: | Palmitoyl-CoA is shown here to inhibit the pH-dependent anion-conducting channel (IMAC) in the inner membrane of rat liver mitochondria, with half-maximal inhibition at 2.4 μM. It has little effect on the transport of ribose, thiocyanate and glutamate. Palmitic acid and palmitoyl-carnitine stimulate the entry of all the above metabolises. CoASH and carnitine have no effect on chloride uniport. Palmitoyl-CoA and the IMAC may have a role in controlling thermogenesis in liver mitochrondria. |
| Databáze: | OpenAIRE |
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