Complement activation in Puumala hantavirus infection correlates with disease severity
| Autor: | Satu Mäkelä, Antti Paakkala, Hanna Jarva, Seppo Meri, Olli Vapalahti, Jussi Sane, Jukka Mustonen, Antti Vaheri, Outi Laine |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Complement Membrane Attack Complex Biology Puumala virus Severity of Illness Index Pathogenesis Young Adult 03 medical and health sciences Severity of illness Humans Prospective Studies Young adult Prospective cohort study Complement Activation Aged 030304 developmental biology Hantavirus 0303 health sciences 030306 microbiology Complement C4 Complement C3 General Medicine Middle Aged biology.organism_classification 3. Good health Complement system Complement (complexity) Hemorrhagic Fever with Renal Syndrome Immunology Female |
| Zdroj: | Annals of Medicine. 44:468-475 |
| ISSN: | 1365-2060 0785-3890 |
| DOI: | 10.3109/07853890.2011.573500 |
| Popis: | Hantaviruses are important human pathogens that cause clinical diseases characterized by renal and cardiopulmonary manifestations. Their pathogenesis is currently poorly understood. We have studied the role of the complement system in the pathogenesis of Puumala (PUUV) hantavirus infection.We studied the activation of complement by measuring the terminal complement complex SC5b-9 and complement component C3 and C4 levels in patients with acute PUUV infection. Several laboratory parameters and clinical findings reflecting the severity of PUUV-HFRS were evaluated with regard to complement activation.The levels of SC5b-9 were significantly increased and C3 decreased in the acute stage as compared to the levels at full recovery (P0.001). We found that SC5b-9 levels were higher in patients with chest X-ray abnormalities than in patients with a normal X-ray during the acute stage (P = 0.028). Furthermore, SC5b-9 and C3 levels showed significant correlation with several clinical and laboratory parameters that reflect the severity of the acute PUUV infection.We showed that the complement system becomes activated via the alternative pathway in the acute stage of PUUV infection and the level of activation correlates with disease severity. The results further suggest that complement activation may contribute to the pathogenesis of acute PUUV infection. |
| Databáze: | OpenAIRE |
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