Common and well-documented HLA alleles: 2012 update to the CWD catalogue
| Autor: | Jill A. Hollenbach, Marcelo Fernandez-Vina, Jun He, Margareth Torres, William Klitz, Shalini E. Pereira, Harriet Noreen, Pedro Cano, Marcel G.J. Tilanus, Jane Kempenich, Michael D. Varney, Damian Goodridge, Erik H. Rozemuller, Carlheinz Müller, Katharina Fleischhauer, Carolyn Katovich Hurley, Christien Voorter, Martin Maiers, Steven J. Mack, Gottfried Fischer, Steven G.E. Marsh, Alicia Sanchez-Mazas, M. E. Moraes, Elaine F. Reed, AM Little, David Senitzer, Anajane G. Smith, Derek Middleton, Michelle Setterholm, Elizabeth Trachtenberg |
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| Přispěvatelé: | Interne Geneeskunde, MUMC+: DA Transplantatie Immunologie (5), MUMC+: DA TI Staf (9), RS: GROW - School for Oncology and Reproduction |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
common and well-documented
Linkage disequilibrium well-documented allele animal diseases Population Clinical Sciences Immunology Histocompatibility Testing Immunogenetics Human leukocyte antigen Biology Biochemistry Article Databases Genetic ddc:590 Gene Frequency HLA Antigens human leukocyte antigen Terminology as Topic Databases Genetic Genetics Immunology and Allergy Humans Allele education Allele frequency Alleles education.field_of_study General Medicine Histocompatibility allele prevalence Genetics Population Genetic Loci sequence-based typing common allele |
| Zdroj: | Tissue Antigens, 81(4), 194-203. Wiley-Blackwell Tissue Antigens, Vol. 81, No 4 (2013) pp. 194-203 Tissue antigens, vol 81, iss 4 |
| ISSN: | 0001-2815 |
| Popis: | We have updated the catalogue of common and well-documented (CWD) human leukocyte antigen (HLA) alleles to reflect current understanding of the prevalence of specific allele sequences. The original CWD catalogue designated 721 alleles at the HLA-A, -B, -C, -DRB1, -DRB3/4/5, -DQA1, -DQB1, and -DPB1 loci in IMGT (IMmunoGeneTics)/HLA Database release 2.15.0 as being CWD. The updated CWD catalogue designates 1122 alleles at the HLA-A, -B, -C, -DRB1, -DRB3/4/5, -DQA1, -DQB1, -DPA1 and -DPB1 loci as being CWD, and represents 14.3% of the HLA alleles in IMGT/HLA Database release 3.9.0. In particular, we identified 415 of these alleles as being 'common' (having known frequencies) and 707 as being 'well-documented' on the basis of (similar to)140,000 sequence-based typing observations and available HLA haplotype data. Using these allele prevalence data, we have also assigned CWD status to specific G and P designations. We identified 147/151 G groups and 290/415 P groups as being CWD. The CWD catalogue will be updated on a regular basis moving forward, and will incorporate changes to the IMGT/HLA Database as well as empirical data from the histocompatibility and immunogenetics community. This version 2.0.0 of the CWD catalogue is available online at cwd.immunogenomics.org, and will be integrated into the Allele Frequencies Net Database, the IMGT/HLA Database and National Marrow Donor Program's bioinformatics web pages. |
| Databáze: | OpenAIRE |
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