Uveitis in Behçet Disease in a Tertiary Center Over 25 Years: The KKESH Uveitis Survey Study Group
| Autor: | J. Fernando Arevalo, Andres F. Lasave, Mohanna Yousef Al Jindan, Nasser Abdulmohsen Al Sabaani, Ammar M. Al-Mahmood, Yahya A. Al-Zahrani, Hassan A. Al Dhibi, Hassan A. Al-Dhibi, Hanan Nasser Al Shamsi, Sulaiman Mohammad Al Suliman, Mohammed Ali Al Shamrani, Abdulaziz Adel Al Rushood, Mosa Barakat Al Harbi, Hassan Mohamad Al Taweel, Sultan Eidah Al Zaaidi, Turki Abdullah Al Ghamdi, Dhafer Saad Al Qahtani, Vishali Gupta, Igor Kozak |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Visual acuity genetic structures medicine.medical_treatment Saudi Arabia Visual Acuity Glaucoma Macular Edema Uveitis Adrenal Cortex Hormones Ophthalmology medicine Humans Macular edema Retrospective Studies Retinal Vasculitis Retinal vasculitis business.industry Behcet Syndrome Panuveitis Middle Aged Cataract surgery medicine.disease eye diseases Female Steroids sense organs medicine.symptom business Vasculitis Immunosuppressive Agents Follow-Up Studies |
| Zdroj: | American Journal of Ophthalmology. 159:177-184.e2 |
| ISSN: | 0002-9394 |
| Popis: | Purpose To describe the features of Behcet-associated uveitis over a 25-year period. Design Retrospective observational case series. Methods A chart review of patients with Behcet-associated uveitis who were evaluated from January 1986 to December 2011 at King Khaled Eye Specialist Hospital, Saudi Arabia. Demographic data, symptoms, type of uveitis, treatment, and complications were evaluated. The main outcome measures were presenting symptoms, types of uveitis, treatment, and complications. Results There were 132 patients (232 eyes; 102 male [77.3%]) evaluated with age of onset of 36.9 ± 11.4 years. Panuveitis was the most common presentation, affecting 118 patients (89.4%). Episodes were bilateral in 100 patients (75.8%). Baseline best-corrected visual acuity (BCVA) was 20/125 in both eyes. Retinal vasculitis at presentation occurred in 61 eyes (26.3%), occlusive vasculitis in 59 eyes (25.4%), and macular edema in 42 eyes (18.1%). Common therapeutic management included oral corticosteroids in 123 patients (93.2%), intravenous steroid therapy in 35 patients (26.5%), cyclosporine in 98 patients (74.2%), and azathioprine in 65 patients (49.2%). Common anterior segment complications included glaucoma (44 eyes, 19%) and cataracts (34 eyes, 14.7%). The most common posterior segment complication was optic nerve atrophy. Cataract surgery was the most common surgery. At last visit, BCVA was better than 20/50 in 131 eyes (56.5%). Conclusions Behcet-associated uveitis predominantly affects young men in Saudi Arabia. Bilateral panuveitis associated with retinal vasculitis was the most common manifestation. More than 50% of patients maintained 20/50 or better BCVA at final follow-up and were primarily managed with oral corticosteroids and other immunosuppressive agents. |
| Databáze: | OpenAIRE |
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