Angiogenic growth factors and their receptors in first-trimester human decidua of pregnancies further complicated by preeclampsia or fetal growth restriction

Autor: P. Koolwijk, Victor W.M. van Hinsbergh, Frans M. Helmerhorst, Margreet Plaisier, Johannes Erwich, E. Streefland
Přispěvatelé: TNO Kwaliteit van Leven, Science in Healthy Ageing & healthcaRE (SHARE), Reproductive Origins of Adult Health and Disease (ROAHD), Physiology, ICaR - Ischemia and repair
Rok vydání: 2008
Předmět:
Adult
First trimester
medicine.medical_specialty
TISSUES
FACTOR VEGF
Angiogenesis
PATHOGENESIS
HYPOXIA
MESSENGER RIBONUCLEIC-ACIDS
Preeclampsia
Angiopoietin
Pathogenesis
FACTOR EXPRESSION
Growth factor receptor
Pre-Eclampsia
Pregnancy
Internal medicine
medicine
Decidua
Humans
Receptors
Growth Factor
Fetal Growth Retardation
Vascular Endothelial Growth Factor Receptor-1
Angiogenic factors
biology
Fetal growth restriction
Obstetrics and Gynecology
Gene Expression Regulation
Developmental
VILLOUS DEVELOPMENT ORIGINS
medicine.disease
Angiopoietin receptor
Receptor
TIE-2
Vascular Endothelial Growth Factor Receptor-2
Pregnancy Complications
Vascular endothelial growth factor A
Pregnancy Trimester
First
medicine.anatomical_structure
Endocrinology
TIE2
ANGIOPOIETIN-2
embryonic structures
biology.protein
Angiogenesis Inducing Agents
Female
PLACENTAL GROWTH
Zdroj: Plaisier, M, Streefland, E, Koolwijk, P, van Hinsbergh, V W M, Helmerhorst, F M & Erwich, J J H M 2008, ' Angiogenic growth factors and their receptors in first-trimester human decidua of pregnancies further complicated by preeclampsia or fetal growth restriction ', Reproductive Sciences, vol. 15, no. 7, pp. 720-726 . https://doi.org/10.1177/1933719108317300
Reproductive Sciences, 15(7), 720-726. SAGE Publications Inc.
Reproductive Sciences, 7, 15, 720-726
ISSN: 1933-7191
DOI: 10.1177/1933719108317300
Popis: Disturbances in decidual and placental vascular development may play a role in the pathogenesis of pregnancy complications. This study focused on the role of angiogenic factors in the first trimester in the pathogenesis of preeclampsia (PE) and/or fetal growth restriction (FGR). First-trimester decidua was obtained during chorionic villous sampling.The expression of the angiogenic factors was determined by reverse transcriptase polymerase chain reaction and related to the pregnancy outcome. First-trimester decidua expressed all angiogenic factors.The differential expression of angiogenic factors appeared to be more prominent in FGR than in PE. These first-trimester samples provided a unique opportunity to obtain information regarding the onset of PE and FGR. First-trimester changes in angiogenic factor expression may well occur as a compensatory mechanism. This, in turn, may unintentionally set the stage for increased angiogenesis and altered decidual/placental vascular adaptation, which may be part of the pathogenesis of PE and/or FGR. © 2008 by the Society for Gynecologic Investigation. Chemicals / CAS: angiopoietin, 250740-90-0; vasculotropin receptor, 301253-48-5; vasculotropin, 127464-60-2
Databáze: OpenAIRE
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