Antimicrobial resistance patterns of Haemophilus influenzae isolated from patients with meningitis in São Paulo, Brazil
| Autor: | Elisabete José Vicente, I.M. Landgraf, A.M.M. Kobata, S.T. Casagrande |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Physiology
medicine.medical_treatment Immunology Biophysics Microbial Sensitivity Tests Drug resistance Biology medicine.disease_cause Biochemistry beta-Lactamases Microbiology Haemophilus influenzae Antibiotic resistance Ampicillin medicine Humans antimicrobial resistance General Pharmacology Toxicology and Pharmaceutics Child lcsh:QH301-705.5 Meningitis Haemophilus lcsh:R5-920 General Neuroscience Chloramphenicol Ceftriaxone meningitis Drug Resistance Microbial Cell Biology General Medicine medicine.disease Anti-Bacterial Agents lcsh:Biology (General) Child Preschool Beta-lactamase lcsh:Medicine (General) Meningitis Brazil medicine.drug |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Vol 33, Iss 3, Pp 295-300 (2000) Brazilian Journal of Medical and Biological Research, Volume: 33, Issue: 3, Pages: 295-300, Published: MAR 2000 Brazilian Journal of Medical and Biological Research v.33 n.3 2000 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
| ISSN: | 0100-879X |
| DOI: | 10.1590/s0100-879x2000000300006 |
| Popis: | From 1989 to 1995, a total of 391 Haemophilus influenzae isolates were recovered from the cerebrospinal fluid (CSF) of hospitalized patients in São Paulo, Brazil. The majority of strains were isolated from infants aged less than 5 years. Strains belonging to biotype I (64.7%), biotype II (34.5%) and biotype IV (0.76%) were detected. Ninety-nine percent of these strains were serotype b. Minimal inhibitory concentration (MIC) was determined for ampicillin, chloramphenicol and ceftriaxone. The ss-lactamase assay was performed for all strains. The rate of ss-lactamase producer strains ranged from 10 to 21.4% during a period of 7 years, with an overall rate of 13.8%. Of the 391 strains analyzed, none was ss-lactamase negative ampicillin resistant (BLNAR). A total of 9.7% of strains showed resistance to both ampicillin and chloramphenicol; however, 4% of them were resistant to ampicillin only and 2% to chloramphenicol. All strains were susceptible to ceftriaxone and the MIC90 was 0.007 microg/ml, suggesting that ceftriaxone could be an option for the treatment of bacterial meningitis in pediatric patients who have not been screened for drug sensitivity. |
| Databáze: | OpenAIRE |
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