Plasma antibody titres to heat shock proteins‐60, ‐65 and‐70: Their relationship to coronary risk factors in dyslipidaemic patients and healthy individuals

Autor:	Dolores J. Lamb, Gordon A. Ferns, T. Wang, D. P. Lovell, Callum Livingstone, Majid Ghayour-Mobarhan
Rok vydání:	2005
Předmět:	Male medicine.medical_specialty Clinical Biochemistry Gastroenterology Antibodies Risk Factors Internal medicine Heat shock protein medicine Humans HSP70 Heat-Shock Proteins In patient Heat-Shock Proteins Dyslipidemias biology business.industry Coronary risk factors Chaperonin 60 General Medicine Hospital employees Middle Aged medicine.disease Obesity Endocrinology Health Healthy individuals biology.protein Female Antibody Metabolic syndrome business
Zdroj:	Scandinavian Journal of Clinical and Laboratory Investigation. 65:601-614
ISSN:	1502-7686 0036-5513
Popis:	To investigate the factors that may affect antibody titres to heat shock proteins (Hsp)-60, -65 and -70, and serum C-reactive protein (CRP) concentrations in patients with dyslipidaemia and other features of the metabolic syndrome as defined by ATPIII criteria.The study comprised 237 dyslipidaemia patients and 135 healthy individuals recruited from amongst university and hospital employees.Compared to the healthy individuals, the dyslipidaemic patients had higher antibody titres to Hsp-60 (p0.01), Hsp-65 (p0.001) and Hsp-70 (p0.05), and higher serum CRP concentrations (p0.001). The best-fitting multifactorial models revealed that known coronary risk factors explained little of the variation in Hsp antibody titres: 3 % for Hsp-60, 1 % for Hsp-65 and 4 % for Hsp-70 amongst the dyslipidaemic subjects. The corresponding values for the subgroup with the metabolic syndrome were 8 %, 3 % and 1 %, respectively. In contrast, the best-fitting model explained 13.5 % of the variation in serum CRP concentrations among the dyslipidaemic patients, obesity being a major determinant; and 14 % in the subgroup with metabolic syndrome.The higher antibody titres to Hsp-60, -65, and -70 in the dyslipidaemic patients may be related to a heightened state of immunoactivation associated with atherosclerosis in this group. Our data indicate that antibody titres to these Hsps are not associated with the classical coronary risk factors, although serum high sensitivity (hs)CRP concentrations were significantly related to obesity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3166ba75baccf7bddd42b1906e4611 https://doi.org/10.1080/00365510500333858 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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