Clinical and Biochemical Aspects of the Carcinoid Syndrome in Neuroendocrine Tumors of the Abdominal and Retroperitoneal Organs and Its Impact for the Disease Prognosis
| Autor: | A. S. Ogereliev, N. V. Lubimova, S. B. Polikarpova, M. I. Davidov, T. A. Britvin |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Serotonin medicine.medical_specialty Pathology Neuroendocrine tumors Gastroenterology General Biochemistry Genetics and Molecular Biology Young Adult Catecholamines Recurrence Internal medicine Biomarkers Tumor medicine Humans Retroperitoneal Neoplasms Young adult Survival rate Aged Malignant Carcinoid Syndrome business.industry Incidence (epidemiology) General Medicine Middle Aged Prognosis medicine.disease Survival Rate Neuroendocrine Tumors Diarrhea Epinephrine Abdominal Neoplasms medicine.symptom business Carcinoid syndrome Histamine medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 148:803-806 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Overall and relapse-free survival of 238 patients with neuroendocrine tumors of the abdominal and retroperitoneal organs was evaluated with consideration for the presence of the carcinoid syndrome. The incidence of the carcinoid syndrome was 15.6%. The presence of the carcinoid syndrome was inessential for survival and relapse prognosis in patients with neuroendocrine tumors of the abdominal and retroperitoneal organs. A trend to the development of earlier relapses was noted in patients with this syndrome. Diarrhea was found to be a prognostically unfavorable factor. The time of the carcinoid syndrome development was prognostically signifi cant in patients with malignant neuroendocrine tumors. The mean secretion of epinephrine, norepinephrine, and dopamine with daily urine was signifi cantly higher in patients with the carcinoid syndrome. A signifi cant positive correlation between urinary excretion of catecholamines was detected (r=0.53; p |
| Databáze: | OpenAIRE |
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