Segmental and global subclasses of class IV lupus nephritis have similar renal outcomes
| Autor: | Jan A.J.G. van den Brand, Jo H. M. Berden, Catharina M. Haring, Anke Rietveld |
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| Rok vydání: | 2012 |
| Předmět: |
Nephrology
medicine.medical_specialty Pathology Lupus nephritis Cohort Studies chemistry.chemical_compound Clinical Research Internal medicine Humans Medicine Randomized Controlled Trials as Topic Renal disorder [IGMD 9] Creatinine business.industry Incidence (epidemiology) General Medicine Effective primary care and public health [NCEBP 7] medicine.disease Lupus Nephritis Infection and autoimmunity Auto-immunity transplantation and immunotherapy [NCMLS 1] chemistry Renal pathology Meta-analysis Relative risk Kidney Failure Chronic business Cohort study |
| Zdroj: | Journal of the American Society of Nephrology, 23, 1, pp. 149-54 Journal of the American Society of Nephrology, 23, 149-54 |
| ISSN: | 1046-6673 |
| Popis: | Item does not contain fulltext Whether renal outcomes differ between the segmental and global subclasses of diffuse proliferative (class IV) lupus nephritis is unknown. In this meta-analysis, we searched the literature in MEDLINE, EMBASE, five registries of clinical trials, and selected cohort studies and randomized, controlled trials that used the 2003 International Society of Nephrology and Renal Pathology Society classification of lupus nephritis in adult patients. Our endpoint was the composite of doubling of serum creatinine concentration or ESRD. In the eight studies included in the final analysis, the incidence of this endpoint varied between 0% and 67%. A funnel plot and Egger's test did not suggest significant heterogeneity. The meta-analysis did not support a significant difference in renal outcome between the segmental (IV-S) and global (IV-G) subclasses (relative risk for class IV-G versus IV-S, 1.08; 95% confidence interval, 0.68-1.70). Meta-regression did not suggest that ethnicity or duration of follow-up influenced the association between histologic class and renal risk. In conclusion, the rate of doubling of serum creatinine concentration or of ESRD did not differ between patients with class IV-S and those with IV-G lupus nephritis. 01 januari 2012 |
| Databáze: | OpenAIRE |
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