Determination of dose-response reltionship for nebulized ipratropium in asthmatic children
| Autor: | Henry Levison, Geoffrey Worsley, Catherine Mindorff, Fred Vickerson, Farouk Kazim, Alan L. Davis |
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| Rok vydání: | 1984 |
| Předmět: |
Male
Adolescent medicine.drug_class Ipratropium bromide Pharmacology Forced Expiratory Volume Bronchodilator Bronchodilation Humans Medicine Atropine Derivatives Child Asthma Aerosols Dose-Response Relationship Drug business.industry Ipratropium Muscarinic antagonist respiratory system medicine.disease Bronchodilator Agents respiratory tract diseases Anesthesia Pediatrics Perinatology and Child Health Salbutamol Female business medicine.drug |
| Zdroj: | The Journal of Pediatrics. 105:1002-1005 |
| ISSN: | 0022-3476 |
| Popis: | IPRATROPIUM BROMIDE is a quaternary isopropyl derivative of the muscarinic antagonist atropine that has bronchodilator properties when administered topically via the respiratory airways. Because of its quaternary nature, it is poorly absorbed into the bloodstream after direct application into the bronchial tree; the cardiovascular side effects are thus minimal. For these reasons ipratropium could represent a significant advance in therapy, especially considering its alternative mode of action via blockade of the cholinergic system rather than stimulation of ~adrenoceptors. Initial information on ipratropium solution has indicated that a dose of 250 #g can be given safely to preschool children with asthma and that the bronchodilation is comparable to that achieved by salbutamol. ~ The purpose of our study was to determine the optimal dosage of ipratropium solution when administered by aqueous nebulization, by constructing a dose-response curve in children of school age. METHODS |
| Databáze: | OpenAIRE |
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