Antibodies against ARHGDIB are associated with long-term kidney graft loss

Autor: Karlijn A M I van der Pant, Michiel G. H. Betjes, Elena G. Kamburova, Irma Joosten, Jan-Stephan F. Sanders, Laura Bungener, Henny G. Otten, Bram W. Wisse, Adriaan C.A.D. Drop, Elly M. van Duijnhoven, Franka E. van Reekum, Maartje L Gruijters, Mariëlle A C J Gelens, Maarten H. L. Christiaans, Wendy Swelsen, Marc A. Seelen, Sebastiaan Heidt, Johan W. de Fijter, Cornelis E. Hack, Shaikh A. Nurmohamed, Michiel L. Bots, Loes Plaisier, Frederike J. Bemelman, Annechien J. A. Lambeck, Luuk B. Hilbrands, Bouke G. Hepkema, Arjan D. van Zuilen, Frans J. van Ittersum, Andries J. Hoitsma, Neelke C. van der Weerd, Marianne C. Verhaar, Frans H.J. Claas, Eric Spierings, N M Lardy, Paul J M van der Boog, Marije C. Baas, Arnold van der Meer, Tineke Kardol-Hoefnagel, Ineke J. M. ten Berge, Dave L. Roelen, Marcel G.J. Tilanus, Wil A. Allebes, Lotte Wieten, Rowena C A Melchers, Caroline Roozendaal, Christina E.M. Voorter
Přispěvatelé: Nephrology, ACS - Atherosclerosis & ischemic syndromes, ACS - Diabetes & metabolism, AII - Inflammatory diseases, Cardiology, APH - Aging & Later Life, Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Interne Geneeskunde, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, MUMC+: DA TI Staf (9), MUMC+: DA TI Laboratorium (9), MUMC+: MA Nefrologie (9), RS: NUTRIM - R3 - Respiratory & Age-related Health, Oral and Maxillofacial Surgery, Erasmus MC other, Internal Medicine
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Graft Rejection
Male
ARHGDIB
030230 surgery
Gastroenterology
Postoperative Complications
0302 clinical medicine
rho Guanine Nucleotide Dissociation Inhibitor beta
HLA Antigens
Isoantibodies
Risk Factors
Living Donors
Immunology and Allergy
Pharmacology (medical)
Kidney transplantation
education.field_of_study
Kidney
biology
Graft Survival
Hazard ratio
PRETRANSPLANT SENSITIZATION
Clinical Science
Middle Aged
Prognosis
non-HLA antibodies
TARGET
medicine.anatomical_structure
REJECTION
II TYPE-1 RECEPTOR
Original Article
Female
Antibody
non‐HLA antibodies
Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5]
Adult
medicine.medical_specialty
Population
kidney transplantation
Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0]
ANTIGENS
03 medical and health sciences
RISK-FACTOR
Internal medicine
medicine
Journal Article
Humans
Clinical significance
education
Autoantibodies
Retrospective Studies
Transplantation
IDENTIFICATION
business.industry
Autoantibody
medicine.disease
PHOSPHOLIPASE-A2 RECEPTOR
biology.protein
Kidney Failure
Chronic
Renal disorders Radboud Institute for Health Sciences [Radboudumc 11]
ORIGINAL ARTICLES
business
Follow-Up Studies
Zdroj: American Journal of Transplantation
American Journal of Transplantation, 19(12), 3335. Blackwell Publishing Asia Pty Ltd
American Journal of Transplantation, 19(12), 3335-3344. Wiley-Blackwell
Kamburova, E G, Gruijters, M L, Kardol-Hoefnagel, T, Wisse, B W, Joosten, I, Allebes, W A, van der Meer, A, Hilbrands, L B, Baas, M C, Spierings, E, Hack, C E, van Reekum, F E, van Zuilen, A D, Verhaar, M C, Bots, M L, Drop, A C A D, Plaisier, L, Melchers, R C A, Seelen, M A J, Sanders, J S, Hepkema, B G, Lambeck, A J A, Bungener, L B, Roozendaal, C, Tilanus, M G J, Voorter, C E, Wieten, L, van Duijnhoven, E M, Gelens, M A C J, Christiaans, M H L, van Ittersum, F J, Nurmohamed, S A, Lardy, N M, Swelsen, W, van der Pant, K A M I, van der Weerd, N C, ten Berge, I J M, Hoitsma, A, van der Boog, P J M, de Fijter, J W, Betjes, M G H, Heidt, S, Roelen, D L, Claas, F H, Bemelman, F J & Otten, H G 2019, ' Antibodies against ARHGDIB are associated with long-term kidney graft loss ', American Journal of Transplantation, vol. 19, no. 12, pp. 3335-3344 . https://doi.org/10.1111/ajt.15493
American Journal of Transplantation, 19, 12, pp. 3335-3344
American journal of transplantation, 19(12), 3335-3344. Wiley-Blackwell
American Journal of Transplantation. Wiley
American Journal of Transplantation, 19(12), 3335-3344. Wiley
American Journal of Transplantation. Wiley-Blackwell Publishing Ltd
American Journal of Transplantation, 19(12), 3335-3344
American Journal of Transplantation, 19, 3335-3344
ISSN: 1600-6135
3335-3344
DOI: 10.1111/ajt.15493
Popis: The clinical significance of non‐HLA antibodies on renal allograft survival is a matter of debate, due to differences in reported results and lack of large‐scale studies incorporating analysis of multiple non‐HLA antibodies simultaneously. We developed a multiplex non‐HLA antibody assay against 14 proteins highly expressed in the kidney. In this study, the presence of pretransplant non‐HLA antibodies was correlated to renal allograft survival in a nationwide cohort of 4770 recipients transplanted between 1995 and 2006. Autoantibodies against Rho GDP‐dissociation inhibitor 2 (ARHGDIB) were significantly associated with graft loss in recipients transplanted with a deceased‐donor kidney (N = 3276) but not in recipients of a living‐donor kidney (N = 1496). At 10 years after deceased‐donor transplantation, recipients with anti‐ARHGDIB antibodies (94/3276 = 2.9%) had a 13% lower death‐censored covariate‐adjusted graft survival compared to the anti‐ARHGDIB‐negative (3182/3276 = 97.1%) population (hazard ratio 1.82; 95% confidence interval, 1.32‐2.53; P = .0003). These antibodies occur independently from donor‐specific anti‐HLA antibodies (DSA) or other non‐HLA antibodies investigated. No significant relations with graft loss were found for the other 13 non‐HLA antibodies. We suggest that pretransplant risk assessment can be improved by measuring anti‐ARHGDIB antibodies in all patients awaiting deceased‐donor transplantation.
From a multicenter evaluation of kidney transplants, the authors report that the pretransplant presence of autoantibodies against ARHGDIB are associated with long‐term graft loss in recipients transplanted with a deceased donor kidney, independent from donor‐specific HLA antibodies.
Databáze: OpenAIRE
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