FDG PET/CT allowing detection and follow-up of tumor cell transplantation
| Autor: | Nahid Tabibzadeh, Alice Jaillard, Arnaud Scherpereel, Marie Frimat, Vivianne Gnemmi, Christian Noel, C. Baillet, Amandine Beron, Damien Huglo, Romain Perbet |
|---|---|
| Přispěvatelé: | CIC CHU ( Lille)/inserm, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 (GRITA), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de Néphrologie et Transplantation rénale [CHRU-lille], Hôpital Albert Calmette, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Claude Huriez [Lille], CHU Lille, Service d'oncologie médicale (CHRU Lille), Thérapies Laser Assistées par l'Image pour l'Oncologie - U 1189 (ONCO-THAI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille) |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Pathology Lung Neoplasms Cell Transplantation [SDV]Life Sciences [q-bio] medicine.medical_treatment Tumor cells 030230 surgery 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography Parenchyma medicine Humans Radiology Nuclear Medicine and imaging Chemotherapy Kidney business.industry General Medicine Middle Aged medicine.disease Small Cell Lung Carcinoma Transplantation Radiation therapy medicine.anatomical_structure Radiology Lymph business Infiltration (medical) Follow-Up Studies |
| Zdroj: | Annals of Nuclear Medicine Annals of Nuclear Medicine, 2016, Annals of Nuclear Medicine, 30, pp.250-254. ⟨10.1007/s12149-015-1051-x⟩ |
| ISSN: | 1864-6433 0914-7187 |
| DOI: | 10.1007/s12149-015-1051-x |
| Popis: | International audience; After detection of small cell lung cancer in a 67-year-old patient who had donated a kidney 7 months earlier, the graft recipient underwent FDG-PET/CT to determine the presence/absence of tumor cell transmission. It showed abnormal increased uptake of the renal graft, associated with hypermetabolic lymph nodes and hepatic, pulmonary and bone lesions. Emergency graft resection was performed 5 days after PET/CT, permitting immunosuppressive therapy withdrawal. Pathologic examination of the kidney showed parenchymal infiltration by tumor cells compatible with small cell lung cancer. Thereafter, pathologists proved that the recipient's and donor's tumor cells matched using microsatellite markers. FDG-PET/CT was performed in the follow-up and showed progression in the donor despite chemotherapy and radiotherapy. He died a few months later. However, FDG-PET/CT showed a complete metabolic response after only 3 courses of chemotherapy in the recipient. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink