Perinatal outcome in pregnant women with cancer: are there any effects of chemotherapy?

Autor: S. De Carolis, M P De Carolis, Serafina Garofalo, Giovanni Capelli, Valentina Anna Degennaro, Sergio Ferrazzani, Antonio Lanzone, Silvia Salvi
Rok vydání: 2016
Předmět:
Lung Neoplasms
Skin Neoplasms
Uterine Cervical Neoplasms
chemotherapy
Central Nervous System Neoplasms
0302 clinical medicine
Neoplasms
Antineoplastic Combined Chemotherapy Protocols
Infant Mortality
Birth Weight
Medicine
030212 general & internal medicine
Neoplasm Metastasis
Melanoma
reproductive and urinary physiology
Twin Pregnancy
Cause of death
Ovarian Neoplasms
Osteosarcoma
education.field_of_study
Obstetrics
Incidence (epidemiology)
Operative
cancer
perinatal outcome
pregnancy
small gestational age
Adult
Bone Neoplasms
Breast Neoplasms
Colorectal Neoplasms
Congenital Abnormalities
Female
Gestational Age
Hematologic Neoplasms
Humans
Infant
Infant
Newborn
Infant
Small for Gestational Age
Pregnancy
Pregnancy Complications
Neoplastic
Pregnancy Trimester
Second
Premature Birth
Prenatal Exposure Delayed Effects
Retrospective Studies
Stomach Neoplasms
Surgical Procedures
Operative
Oncology
030220 oncology & carcinogenesis
Pregnancy Trimester
medicine.medical_specialty
Population
03 medical and health sciences
education
Neoplastic
Surgical Procedures
business.industry
Cancer
Second
Newborn
medicine.disease
Pregnancy Complications
Settore MED/40 - GINECOLOGIA E OSTETRICIA
Small for Gestational Age
Small for gestational age
business
Postpartum period
Zdroj: European Journal of Cancer Care. 26:e12564
ISSN: 0961-5423
DOI: 10.1111/ecc.12564
Popis: Cancer is the leading cause of death in women of reproductive age. During the last decades and especially in developed countries, the incidence of cancer is increasing dramatically, with an incidence of 1 in 1,000 pregnancies. This is mostly related to delay of pregnancy into the late reproductive years. The aim of this study was to investigate the outcome of pregnancy in women with diagnosis of cancer; in particular, neonatal morbidity and mortality, after in utero exposure to chemotherapy, were evaluated. A total of 59 singletons and one twin pregnancy complicated by cancer were followed at our tertiary centre over the last 15 years. A different treatment, based on surgery and/or chemotherapy in pregnancy or delayed to the postpartum period, was employed. There were 59 live births (97%), one foetal loss and one stillbirth at 28 weeks. The congenital malformation rate was 5% (n = 3). The rate of preterm birth was 83%. The mean birthweight and mean birthweight percentile were 2,098 g (740-3930) and 46 (7-93), respectively; 32% of neonates were small for gestational age (SGA). Dividing the population into treated or untreated with chemotherapy, the rate of SGA was not statistically significant different between the two groups. Our results showed that chemotherapy administered during the second trimester or later did not influence intrauterine foetal growth, but the high prevalence of SGA neonates in the two groups, exposed or not exposed to chemotherapy, suggests an influence of maternal cancer per se on foetal growth.
Databáze: OpenAIRE
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