Quality of Life During Chemotherapy for Small Cell Lung Cancer :I. An evaluation with generic health measures
| Autor: | S. Sörenson, Bengt Bergman, M. Sullivan |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Anxiety Hospital Anxiety and Depression Scale Quality of life Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Carcinoma Small Cell Lung cancer Aged Aged 80 and over Chemotherapy Performance status Depression business.industry Respiratory disease Hematology General Medicine Middle Aged medicine.disease Surgery Affect Oncology Quality of Life Non small cell business Psychosocial Follow-Up Studies |
| Zdroj: | Acta Oncologica. 30:947-957 |
| ISSN: | 1651-226X 0284-186X |
| DOI: | 10.3109/02841869109088248 |
| Popis: | The Sickness Impact Profile (SIP) and the Hospital Anxiety and Depression scale (HAD) were used for assessment of physical and psychosocial functioning and emotional distress in patients with small cell lung cancer (SCLC) receiving chemotherapy. Treatment schedules extended over 12 months. Before treatment sixty-two patients, 36-80 years of age, completed the questionnaires and a selection of lung cancer symptom items. Approximately 50% of the patients reported clinically significant physical dysfunction, while emotional distress was reported by 25% and social restraints by 40%. Self-reported overall dysfunction, as assessed by SIP total index, was clinically significant in 60% of the patients. SIP physical and total indices were strongly related to WHO performance status (grade 0-4). The assessment was subsequently repeated every third month during the treatment period. Overall tumour response rate was 82%. The changes of physical and psychosocial functioning, as assessed by SIP, were significantly related to tumour response, although a persistent substantial overall dysfunction was shown among 50% of the responders after 3 months and among c. 40% after 6 months. In addition to tumour response, pain and appetite changes correlated with the change of overall SIP in multivariate analysis, implying the importance of pain control and appetite stimulating measures for patients with advanced cancer. Anxiety and depression, as measured by HAD, were reduced in 21 patients who completed 12 months chemotherapy, but only anxiety co-varied with tumour response. The results lend support to the use of the generic SIP and HAD as outcome measures in clinical research with SCLC patients receiving chemotherapy. |
| Databáze: | OpenAIRE |
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