The International Immune Tolerance Induction Study and its follow-up study on Japanese hemophilia A patients with inhibitors

Autor: Masashi Taki, Masao Kobayashi, Michio Sakai, Hisato Kigasawa, Keiji Nogami, Ryoji Kobayashi, Akira Yoshioka, Ikuya Usami, Eizaburo Ishii, Midori Shima, Tamaki Ueno, Takashi Suzuki, Manabu Sotomatsu, Katsuyuki Fukutake, Tadashi Matsushita, Akira Shirahata, Yasushi Ishida
Rok vydání: 2015
Předmět:
Zdroj: International Journal of Hematology. 101:362-368
ISSN: 1865-3774
0925-5710
Popis: The International Immune Tolerance Induction (I-ITI) Study in hemophilia A patients with inhibitors included 16 Japanese patients among a total of 115 test subjects. The results within this group of Japanese patients were 11 cases of I-ITI off-study, three cases of I-ITI on-study, and two cases of tolerance on prophylaxis. There was no significant difference in success rate between the low-dose and high-dose groups (Study I). Successively, independent follow-up survey in Japan was conducted in 14 cases, with consent (Study II). Ten cases were off-study at the end of the I-ITI Study. Of these 10 cases, seven of seven successful cases remained clinical successes at the end of the follow-up study, one partial success became a full success while a second relapsed, and one failure was subsequently evaluated as a partial success. Four cases that were on-study at the end of I-ITI Study were classified as three successes and one failure at the end of the follow-up study. As a result, the status at the end of follow-up study was: 11 ITI successes (78.6 %); one partial success; one failure; and one relapse. Thus, the ITI follow-up study was helpful in providing a long-term prognostic determination of inhibitors.
Databáze: OpenAIRE
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