Estimation of bone permeability considering the morphology of lacuno-canalicular porosity
| Autor: | Narumichi Sato, Yoshitaka Kameo, Taiji Adachi, Masaki Hojo |
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| Rok vydání: | 2010 |
| Předmět: |
Microscopy
Confocal Materials science Poromechanics Biomedical Engineering Mineralogy Bone canaliculus Models Biological digestive system Radial direction Bone and Bones Permeability Molecular Imaging Biomaterials Permeability (earth sciences) Mechanics of Materials Interstitial fluid Volume fraction Animals Anisotropy Composite material Porosity |
| Zdroj: | Journal of the Mechanical Behavior of Biomedical Materials. 3:240-248 |
| ISSN: | 1751-6161 |
| DOI: | 10.1016/j.jmbbm.2009.10.005 |
| Popis: | Load-induced interstitial fluid flow in lacuno-canalicular porosity is believed to play an important role in cellular activities regulating adaptive bone remodeling. To investigate interstitial fluid behavior based on poroelasticity, it is important to determine the anisotropic permeability tensor reflecting the morphological features of the lacuno-canalicular porosity as fluid channels. In this study, we presented an estimation method of trabecular permeability by describing the analytical relationship between the volume orientation (VO) fabric tensor, which represents the canalicular orientation, and the permeability tensor. The relationship showed that the trabecular permeability tensor is proportional to the product of the volume fraction of the interstitial fluid and the VO fabric tensor of the canaliculi. We applied the proposed method to a two-dimensional fluorescent image of a trabecular cross section to quantify the canalicular anisotropy and the trabecular permeability tensor. The results indicated that the canaliculi are predominantly oriented in the radial direction of the trabecula, and the permeability depends strongly on the canalicular morphology. |
| Databáze: | OpenAIRE |
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