Characterization of Biomarkers in Colorectal Cancer Liver Metastases as a Prognostic Tool
| Autor: | Ben Aharon Irit, Brenner Baroch, Kashtan Hanoch, Perl Gali, Brook Elana, Haddad Riad, Goldenfeld Miki, Goshen-Lago Tal, Sternschuss Michal |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Poor prognosis medicine.medical_specialty Multivariate analysis business.industry Colorectal cancer Medicine (miscellaneous) biomarkers Perioperative Disease colorectal cancer liver metastasis medicine.disease molecular signature Article hepatic surgery Internal medicine Hepatic surgery Cohort medicine Medicine prognosis Prospective cohort study business |
| Zdroj: | Journal of Personalized Medicine Volume 11 Issue 11 Journal of Personalized Medicine, Vol 11, Iss 1059, p 1059 (2021) |
| ISSN: | 2075-4426 |
| DOI: | 10.3390/jpm11111059 |
| Popis: | Background: Unfortunately, the majority of patients with colorectal cancer liver metastases (CRCLM) experience disease recurrence following hepatic surgery. The key challenge is therefore optimal patient selection, which currently relies on anatomical and clinical parameters. Exploring a potential molecular signature may be predictive for seeing a clinical benefit from CRCLM resection. Methods: Consecutive patients who underwent CRCLM resection at our medical center between 2006 and 2016 were divided into cohorts of “good prognosis” (GP) or “poor prognosis” (PP) based on the time interval between their resection and disease recurrence. Proteomic analysis was performed on the surgical specimen and correlation analysis was carried out with demographics and clinical outcomes. Results: Proteomic analysis revealed 99 differentially expressed proteins of which a third were associated with extracellular matrix (ECM) pathways as the matrix metalloproteinases (MMPs). Multivariate analysis yielded a statistically differential proteomic pattern between the cohort regardless of perioperative treatment. Conclusion: Our results indicate a different proteomic landscape in the cohort of patients who had a clinical benefit from CRCLM resection which appears to be correlated with ECM pathways. Further prospective studies are needed to define the role of ECM pathways in prognostics and patient selection for surgical procedures for CRCLM. |
| Databáze: | OpenAIRE |
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