| Autor: |
Xin Yan, Pengfei Li, Yanrong Zhang, Connor Hensley, Shanshan Hou, Steffen Jockusch, Thomas D. Legalley, K. Michael Gibson, Lanrong Bi, Wei Bi, Yue Bi |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
ACS Omega, Vol 4, Iss 6, Pp 9868-9877 (2019) |
| ISSN: |
2470-1343 |
| DOI: |
10.1021/acsomega.8b02441 |
| Popis: |
We recently designed and synthesized a series of novel levodopa–peptide–TEMPO conjugates (LPTCs). Among these compounds, LPTC-5 possesses both free-radical scavenging potential and mitochondrial fusion-promoting activity. The free-radical scavenging capacity of LPTC-5 was confirmed using a PC12 cell survival assay. LPTC-5 could restore the mitochondrial tubular network following genetically induced fragmentation. The therapeutic efficacy of LPTC-5 was then examined employing in vitro and in vivo ischemia/reperfusion (I/R) models. LPTC-5 protected cells from mitochondrial reactive oxygen species overproduction and inhibited cytochrome c release in a simulated I/R cellular model. Additionally, LPTC-5 attenuated organ damage in a cardiac I/R animal model. The data suggest that LPTC-5 exerts cardioprotection via modulation of mitochondrial fission/fusion dynamics, ultimately improving mitochondrial function and cardiac function. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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