IGFBP-2 Partly Mediates the Early Metabolic Improvements Caused by Bariatric Surgery

Autor: R. Leigh Townsend, André C. Carpentier, Stéfane Lebel, Anne-Marie Carreau, Elena-Dana Baraboi, Heike Münzberg, André Tchernof, Frédéric Picard, Hans-Rudolf Berthoud, Denis Richard, Frédéric-Simon Hould, Thomas Grenier-Larouche, Meng Li, Zheng Hao, Justine Faramia, Christopher D. Morrison, Simon Marceau, Frédérique Frisch, Michael B. Mumphrey, Christophe Noll, Stéphanie Miard, Laurent Biertho, Mélanie Nadeau
Rok vydání: 2020
Předmět:
Medicine (General)
medicine.medical_specialty
Sleeve gastrectomy
mice
Biochemical Phenomena
bariatric surgery
medicine.medical_treatment
Gastric Bypass
binding protein
030209 endocrinology & metabolism
Type 2 diabetes
patients
Article
General Biochemistry
Genetics and Molecular Biology
insulin-like growth factor
03 medical and health sciences
Insulin-like growth factor
R5-920
0302 clinical medicine
RYGB
Gastrectomy
0502 economics and business
medicine
Animals
Humans
Glucose homeostasis
Obesity
050207 economics
Sensitization
Biliopancreatic Diversion
030304 developmental biology
0303 health sciences
050208 finance
business.industry
Insulin
05 social sciences
medicine.disease
Duodenal switch
Obesity
Morbid
Surgery
Insulin-Like Growth Factor Binding Protein 2
BPD-DS
medicine.anatomical_structure
type 2 diabetes
business
metabolism
sleeve gastrectomy
Zdroj: Cell Reports Medicine, Vol 2, Iss 4, Pp 100248-(2021)
Cell Reports Medicine
ISSN: 1556-5068
DOI: 10.2139/ssrn.3667141
Popis: Summary Insulin-like growth factor-binding protein (IGFBP)-2 is a circulating biomarker of cardiometabolic health. Here, we report that circulating IGFBP-2 concentrations robustly increase after different bariatric procedures in humans, reaching higher levels after biliopancreatic diversion with duodenal switch (BPD-DS) than after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). This increase is closely associated with insulin sensitization. In mice and rats, BPD-DS and RYGB operations also increase circulating IGFBP-2 levels, which are not affected by SG or caloric restriction. In mice, Igfbp2 deficiency significantly impairs surgery-induced loss in adiposity and early improvement in insulin sensitivity but does not affect long-term enhancement in glucose homeostasis. This study demonstrates that the modulation of circulating IGFBP-2 may play a role in the early improvement of insulin sensitivity and loss of adiposity brought about by bariatric surgery.
Graphical abstract
Highlights IGFBP-2 is modulated by different bariatric surgeries in both human and rodents In humans, IGFBP-2 levels are closely related to insulin sensitization In mice, IGFBP-2 partly mediates surgery-induced weight loss IGFBP-2 is implicated in surgery-induced early improvements in glucose homeostasis
Faramia et al. show that the robust increase in IGFBP-2 levels is a common feature of bariatric procedures in humans and rodents. In patients, this increase closely correlates with insulin sensitization. In mice, IGFBP-2 deficiency partly impairs weight loss and early improvements in glucose homeostasis induced by Roux-en-Y surgery.
Databáze: OpenAIRE
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