Evaluation of the effect of Carvacrol on retinal neovascularization in rats
| Autor: | Abdulgani Kaymaz, Sevilay Erimsah |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Bevacizumab
business.industry General Engineering Nuclear factor κb Pharmacology Bevacizumab carvacrol neovascularization nuclear factor-κB oxygen-induced retinopathy retinal vascular endothelial cell Oxygen induced retinopathy Neovascularization chemistry.chemical_compound Retinal neovascularization Veterinary chemistry General Earth and Planetary Sciences Medicine Veteriner Hekimlik Carvacrol medicine.symptom business General Environmental Science medicine.drug |
| Zdroj: | Volume: 5, Issue: 1 35-40 Turkish Journal of Veterinary Research |
| ISSN: | 2602-3695 |
| Popis: | Objectives: To compare the effect of intraperitoneal administered Carvacrol with bevacizumab in an oxygen-induced retinopathy (OIR) model in rats.Materials and Methods: Twenty-eight newborn rats were included in the study and the OIR model was created with the 50/10% oxygen style. The study consisted of 4 groups and each rat in the groups received an intraperitoneal injection of 0.01 mL once on the postnatal 14th day. While the OIR model was not created in Group I (control group), it was created for Groups II, III, and IV. Groups I and II were injected with 0.9% NaCl solution, Group III with bevacizumab, and Group IV with carvacrol. The rats were sacrificed on the postnatal 18th day. Results: Histopathological and immunohistochemical studies showed that the number of retinal vascular endothelial cells (RVECs) and nuclear factor (NF)-κB levels decreased similarly in Group III and Group IV compared to Group II. RVECs values for Group I, Group II, Group III and Group IV were measured as 1.26±0.80, 27.10±3.63, 7.54±1.38, and 6.22±1.22, respectively and it differed significantly between groups (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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