Thermoregulatory activity of sodium nitroprusside and arginine vasopressin
| Autor: | M.T. Matuszek, Piotr Rekowski, E.E. Hac, G. Kupryszewski, Korolkiewicz Kz, I.T. Gagalo |
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| Rok vydání: | 1995 |
| Předmět: |
Lipopolysaccharides
Male Nitroprusside medicine.medical_specialty Vasopressin Arginine Hemodynamics Blood Pressure Internal medicine medicine Animals Ear External Pharmacology Lagomorpha biology Chemistry Pyrogens Respiration Hypothermia Thermoregulation biology.organism_classification Arginine Vasopressin Endocrinology Blood pressure Metabolism Female Sodium nitroprusside Rabbits medicine.symptom Skin Temperature medicine.drug Body Temperature Regulation |
| Zdroj: | General pharmacology. 26(2) |
| ISSN: | 0306-3623 |
| Popis: | 1. 1. Thermal responses to sodium nitroprusside (SNP, 3 mg/kg/hr) and arginine vasopressin (AVP, 3μg/kg) were investigated in normothermic and febrile rabbits (LPS, 1μg/kg) at ambient temperature of 20.0 ±1.0°C. Furthermore, blood pressure after these drugs was tested on a separate group of animals. 2. 2. I.v. infusion of SNP produced hypothermia and attenuated pyrogen fever. On the other hand, AVP increased body temperature and intensified the febrile response. 3. 3. Both drugs affected in an opposite way blood pressure, i.e. SNP produced falls and AVP increases in this parameter. 4. 4. The relationship between the activity of the vascular and thermoregulatory systems in normothermic or febrile state is discussed. |
| Databáze: | OpenAIRE |
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