Relationship between pyrophosphate, amorphous calcium phosphate and other factors in the sequence of calcificationin vivo
| Autor: | Herbert Fleisch, R. E. Wuthier, Roslin Russell, S. Bisaz |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Calcium Phosphates
Endocrinology Diabetes and Metabolism chemistry.chemical_element Calcium Pyrophosphate Bone and Bones chemistry.chemical_compound Calcification Physiologic Fetus Endocrinology Dry weight Polysaccharides Periosteum medicine Animals Magnesium Orthopedics and Sports Medicine Femur Amorphous calcium phosphate Phospholipids Tibia Cartilage Single factor General Medicine medicine.disease Diphosphates medicine.anatomical_structure chemistry Biochemistry Cattle Collagen Hydroxyapatites Crystallization Calcification |
| Zdroj: | Calcified Tissue Research. 10:198-206 |
| ISSN: | 1432-0827 0008-0594 |
| Popis: | The amounts of inorganic pyrophosphate (PPi), orthophosphate and calcium have been measured in resting, proliferating, hypertrophic and calcified cartilage from foetal calf epiphyses and also in cancellous, periosteal and compact bone. In the cartilage samples, the content of PPi increased progressively in the order named above, from values of 8.59 μg P/g dry weight in resting cartilage to 236 μg P/g dry weight in calcified cartilage. However, the ratio of PPi to orthophosphate followed the reverse relationship and was highest in the resting zone and fell dramatically as the tissue calcified. The possible role of PPi in inhibiting the precipitation of amorphous calcium phosphate (ACP) and in the slowing the transformation of ACP to hydroxyapatite (HA) in calcifying tissues is discussed in relation to other factors, such as collagen, magnesium, phospholipids and proteinpolysaccharides, which might also influence the processin vivo. At present, no single factor can be identified as a proven physiological regulator. |
| Databáze: | OpenAIRE |
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