A biocompatible and easy-to-make polyelectrolyte dressing with tunable drug delivery properties for wound care
| Autor: | Tik Hung Tsoi, Guoxing Deng, Chengshen Hu, Wing Tak Wong, Kwok Ho Lui, Wing-Fu Lai, Xiao Wang, Shaoxiang Wang |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
Cell Survival Static Electricity Pharmaceutical Science Minocycline 02 engineering and technology 030226 pharmacology & pharmacy Chitosan Mice 03 medical and health sciences chemistry.chemical_compound Wound care Drug Delivery Systems 0302 clinical medicine Animals Wound treatment Mice Inbred ICR Wound Healing integumentary system 3T3 Cells equipment and supplies 021001 nanoscience & nanotechnology Biocompatible material Bandages Polyelectrolytes Polyelectrolyte Anti-Bacterial Agents chemistry Carboxymethylcellulose Sodium Drug delivery Female Wound closure 0210 nano-technology Wound healing human activities Biomedical engineering |
| Zdroj: | International Journal of Pharmaceutics. 566:101-110 |
| ISSN: | 0378-5173 |
| DOI: | 10.1016/j.ijpharm.2019.05.045 |
| Popis: | Chitosan (CS) is a biodegradable and biocompatible polysaccharide which displays immune-stimulatory effects and anti-bacterial properties to facilitate wound closure. Over the years, different CS-based dressings have been developed; however, most of them are not fully biodegradable due to the involvement of synthetic polymers during dressing fabrication. In addition, preparation of many of these dressings is laborious, and may impose damaging effects on fragile therapeutic molecules. The objective of this study is to address these problems by developing a tunable, biocompatible, and biodegradable CS-based dressing for wound treatment. The dressing is fabricated via electrostatic interactions between CS and carmellose (CM). Its swelling properties, erosion behavior, loading efficiency and drug release sustainability can be tuned by simply changing the CS/CM mass-to-mass ratio. Upon loaded with minocycline hydrochloride, the dressing effectively protects the wound in mice from infection and enhances wound closure. Regarding its high tunability and promising in vivo performance, our dressing warrants further development as a user-friendly dressing for use in wound care. |
| Databáze: | OpenAIRE |
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