A Photocatalytic Regioselective Direct Hydroaminoalkylation of Aryl-Substituted Alkenes with Amines

Autor:	Xacobe C. Cambeiro, Jun Miyatake Ondozabal, Emily G. Smith, Natalia A. Larionova
Rok vydání:	2021
Předmět:	010405 organic chemistry Chemistry Continuous flow Radical Aryl Organic Chemistry Regioselectivity 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound Aniline Photocatalysis Organic chemistry Physical and Theoretical Chemistry Selectivity
Zdroj:	Organic letters. 23(14)
ISSN:	1523-7052
Popis:	A photocatalytic method for the α-selective hydroaminoalkylation of cinnamate esters has been developed. The reaction involves the regioselective addition of α-aminoalkyl radicals generated from aniline derivatives or aliphatic amines to the α-position of unsaturated esters. The scope of aromatic alkenes was extended to styrenes undergoing hydroaminoalkylation with anti-Markovnikov selectivity, which confirms the importance of the aromatic group at the β-position. Simple scale-up is demonstrated under continuous flow conditions, highlighting the practicality of the method.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1cc33465794873d7f771118ffbf9d2 https://pubmed.ncbi.nlm.nih.gov/34197124 Zobrazit plný text záznamu