Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer

Autor: Reinier O. Schlingemann, Andrea Weiss, Li Shen, Tse J. Wong, Roberto Pili, Marchien G. Dallinga, Olivier Dormond, Chih-Ming Ho, Arjan W. Griffioen, Hubert van den Bergh, Paul J. Dyson, Judy R. van Beijnum, Patrycja Nowak-Sliwinska, Xianting Ding, Ieong Wong, Robert H. Berndsen
Přispěvatelé: Medical oncology laboratory, CCA - Innovative therapy, Graduate School, ACS - Amsterdam Cardiovascular Sciences, ANS - Amsterdam Neuroscience, Ophthalmology
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Cancer Research
Physiology
Angiogenesis
Clinical Biochemistry
Cell Culture Techniques
Apoptosis
Drug resistance
Pharmacology
Chorioallantoic Membrane
Mice
Anti-angiogenesis
Cell Movement
Neoplasms
Antineoplastic Combined Chemotherapy Protocols
media_common
Ovarian Neoplasms
education.field_of_study
Neovascularization
Pathologic
Imidazoles
Search algorithm
3. Good health
Endothelial stem cell
Platelet Endothelial Cell Adhesion Molecule-1
Quinolines
Female
Erlotinib
Algorithms
medicine.drug
Drug
Drug–drug interactions
Combination therapy
Cell Survival
media_common.quotation_subject
Population
Mice
Nude
Feedback system control
Biology
Feedback
In vivo
Cell Line
Tumor
medicine
Organometallic Compounds
Animals
Humans
Drug-drug interactions
education
Stochastic Processes
Original Paper
Endothelial Cells
Cymenes
Drug Screening Assays
Antitumor
Chickens
Neoplasm Transplantation
Zdroj: Angiogenesis, vol. 18, no. 3, pp. 233-244
Weiss, A, Ding, X T, van Beijnum, J R, Wong, I, Wong, T J, Berndsen, R H, Dormond, O, Dallinga, M, Shen, L, Schlingemann, R O, Pili, R, Ho, C M, Dyson, P J, van den Bergh, H, Griffioen, A W & Nowak-Sliwinska, P 2015, ' Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer ', Angiogenesis, vol. 18, no. 3, pp. 233-244 . https://doi.org/10.1007/s10456-015-9462-9
Angiogenesis, 18(3), 233-244. Springer Netherlands
Angiogenesis
Weiss, A; Ding, X; van Beijnum, JR; Wong, I; Wong, TJ; Berndsen, RH; et al.(2015). Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer. Angiogenesis, 18(3), 233-244. doi: 10.1007/s10456-015-9462-9. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1f05g517
ISSN: 0969-6970
DOI: 10.1007/s10456-015-9462-9
Popis: Drug combinations can improve angiostatic cancer treatment efficacy and enable the reduction of side effects and drug resistance. Combining drugs is non-trivial due to the high number of possibilities. We applied a feedback system control (FSC) technique with a population-based stochastic search algorithm to navigate through the large parametric space of nine angiostatic drugs at four concentrations to identify optimal low-dose drug combinations. This implied an iterative approach of in vitro testing of endothelial cell viability and algorithm-based analysis. The optimal synergistic drug combination, containing erlotinib, BEZ-235 and RAPTA-C, was reached in a small number of iterations. Final drug combinations showed enhanced endothelial cell specificity and synergistically inhibited proliferation (p
Databáze: OpenAIRE
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