A prospective, randomized, double-blind comparison of epidural levobupivacaine 0.5% with epidural ropivacaine 0.75% for lower limb procedures
| Autor: | Rosalba Tufano, Montanini S, V. A. Peduto, Andrea Casati, Simonetta Baroncini, Rodolfo Proietti, L. Rosignoli |
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| Přispěvatelé: | V. A., Peduto, S., Baroncini, S., Montanini, R., Proietti, L., Rosignoli, Tufano, Rosalba, A., Casati |
| Rok vydání: | 2003 |
| Předmět: |
Adult
Anesthesia Epidural Male medicine.medical_specialty Time Factors medicine.drug_class Movement Analgesic Sensation Pain Lower limb Fentanyl Double blind Motor block Double-Blind Method Humans Medicine Ropivacaine Prospective Studies Anesthetics Local Levobupivacaine Analysis of Variance Dose-Response Relationship Drug business.industry Local anesthetic Amides Bupivacaine Surgery Treatment Outcome Anesthesiology and Pain Medicine Lower Extremity Anesthesia Female business medicine.drug |
| Zdroj: | European Journal of Anaesthesiology. 20:979-983 |
| ISSN: | 0265-0215 |
| Popis: | SummaryBackground and objective: This prospective, randomized, observer-blinded study compared onset time and duration of epidural anaesthesia produced by with levobupivacaine and ropivacaine for lower limb surgery.Methods: ASA I–III adult patients undergoing elective lower limb procedures were randomized to receive epidural levobupivacaine 0.5% 15 mL (n = 30) or epidural ropivacaine 0.75% 15 mL (n = 35). A blinded observer evaluated onset time and regression of motor and sensory block, and intraoperative needs for fentanyl supplementation (0.1 mg intravenously).Results: With levobupivacaine, onset time was 29 ± 24 min, with ropivacaine it was 25 ± 22 min (P = 0.41). Complete resolution of motor block required 105 ± 63 min with levobupivacaine and 95 ± 48 min with ropivacaine (P = 0.86). The time for regression of sensory block to T12 was 185 ± 77 min with levobupivacaine and 201 ± 75 min with ropivacaine (P = 0.46). Analgesic supplementation was required in one patient receiving levobupivacaine (3.5%) and in two patients receiving ropivacaine (5.7%) (P = 0.99).Conclusions: In adults undergoing lower limb surgery, levobupivacaine 0.5% 15 mL produces an epidural block with the same clinical profile as ropivacaine 0.75% 15 mL. |
| Databáze: | OpenAIRE |
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