Effects of statins on multispecies oral biofilm identify simvastatin as a drug candidate targetingPorphyromonas gingivalis

Autor: Marta Kamińska, Veronika Binder, Tomasz Kantyka, Ardita Aliko, Jan Potempa, Agata Marczyk, Annelie Hellvard, Ewa Bielecka, Piotr Mydel, Nicolas Delaleu
Rok vydání: 2018
Předmět:
Zdroj: J Periodontol
ISSN: 1943-3670
0022-3492
Popis: BACKGROUND: Statins effectively reduce risk of cardiovascular-related morbidity and mortality in patients with hyperlipidemia, hypertension or type-II diabetes. In addition to lowering cholesterol levels, several studies have attributed statins with immunomodulatory and bactericidal properties. Therefore, the aim of this study was to investigate statins’ antimicrobial activity against relevant for periodontal homeostasis bacteria. METHODS: Statin effect on bacterial growth was tested using planktonic monocultures and multibacterial biofilms. The latter consisted of five microbial species (Porphyromonas gingivalis, Fusobacterium nucleatum, Actinomyces naeslundii, Tannerella forsythia, Streptococcus gordonii) associated with dysbiosis of the oral microbiota underlying establishment and perpetuation of periodontitis. RESULTS: All four tested statins efficiently inhibited P. gingivalis growth and significantly decreased the cumulative bacterial load in developing and established biofilms. Simvastatin was most efficient and decreased P. gingivalis counts more than 1300-fold relative to the control. CONCLUSIONS: These findings suggest that similar effects on bacterial composition of the dental plaque may occur in vivo in patients on statins thus leading to a shift of the oral microbiome from a dysbiotic to a more homeostatic one. Simvastatin, being highly effective against P. gingivalis while not affecting commensal microbiota, possesses many properties qualifying it as a potential adjunctive treatment for chronic periodontitis. Further studies are needed to evaluate whether similar effects on bacterial composition of the dental plaque may occur in vivo in patients on statins thus leading to a shift of the oral microflora from dysbiotic to a more homeostatic one.
Databáze: OpenAIRE
Externí odkaz: