The Influence of the Val158Met Catechol-O-Methyltransferase Polymorphism on the Personality Traits of Bipolar Patients

Autor: Ricardo Dávila, Wendy Dávila, María I. Zamalloa, Aurora Arrúe, Miguel Angel Gonzalez-Torres, Mercedes Zumárraga, Estibaliz Gordo, Nieves Basterreche
Rok vydání: 2013
Předmět:
psychometrics
Male
Persistence (psychology)
Bipolar Disorder
personality tests
BIOCHEMISTRY AND MOLECULAR BIOLOGY
Dopamine
II disorder
lcsh:Medicine
Biochemistry
Psychology
Medicine
lcsh:Science
media_common
manic-depressive patients
Psychiatry
Multidisciplinary
Neurochemistry
Middle Aged
Mental Health
AGRICULTURAL AND BIOLOGICAL SCIENCES
Harm avoidance
Female
dopamine
Neurochemicals
Research Article
Personality
Adult
medicine.medical_specialty
Genotype
media_common.quotation_subject
functional polymorphism
Catechol O-Methyltransferase
Young Adult
Quantitative Trait
Heritable
mental disorders
Genetics
Humans
personality disorders
Bipolar disorder
Biology
Polymorphism
Genetic
MEDICINE
Mood Disorders
business.industry
lcsh:R
Cooperativeness
Novelty seeking
Psychoses
medicine.disease
Personality disorders
Case-Control Studies
personality traits
Genetic Polymorphism
lcsh:Q
Temperament and Character Inventory
Molecular Neuroscience
business
dopaminergics
Population Genetics
Neuroscience
Zdroj: PLoS ONE
PLoS ONE, Vol 8, Iss 4, p e62900 (2013)
Addi. Archivo Digital para la Docencia y la Investigación
instname
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0062900
Popis: 6 p. Introduction: Certain personality traits and genetic polymorphisms are contributing factors to bipolar disorder and its symptomatology, and in turn, this syndrome influences personality. The aim of the present study is to compare the personality traits of euthymic bipolar patients with healthy controls and to investigate the effect of the catechol-O-methyltransferase (COMT) Val158Met genotype on those traits. We recruited thirty seven bipolar I patients in euthymic state following a manic episode and thirty healthy controls and evaluated their personality by means of the Cloninger's Temperament and Character Inventory (version TCI-R-140). We assessed the influence of the polymorphism Val158Met in the COMT gene on the personality of these patients. The patients scored higher than controls in harm avoidance (61.3 +/- 12.5 vs. 55.3 +/- 8.1) and self-transcendence (45.3 +/- 12.8 vs. 32.7 +/- 8.2) and scored lower than controls in self-directedness (68.8 +/- 13.3 vs. 79.3 +/- 8.1), cooperativeness (77.1 +/- 9.1 vs. 83.9 +/- 6.5) and persistence (60.4 +/- 15.1 vs. 67.1 +/- 8.9). The novelty seeking dimension associates with the Val158Met COMT genotype; patients with the low catabolic activity genotype, Met/Met, show a higher score than those with the high catabolic activity genotype, Val/Val.-- Conclusions: Suffering from bipolar disorder could have an impact on personality. A greater value in harm avoidance may be a genetic marker for a vulnerability to the development of a psychiatric disorder, but not bipolar disorder particularly, while a low value in persistence may characterize affective disorders or a subgroup of bipolar patients. The association between novelty seeking scores and COMT genotype may be linked with the role dopamine plays in the brain's reward circuits. Supported in part by grant 2008111051 of the Basque Government’s Department of Health and by Grant PS0901760 of the Fondo de Investigación Sanitaria and FEDER Funds, Spain. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Databáze: OpenAIRE
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