Amygdala and hippocampus are symptomatogenic zones for central apneic seizures
| Autor: | Luisa V. Londoño, Bilal Zonjy, Samden D. Lhatoo, Nuria Lacuey |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Drug Resistant Epilepsy Apnea Central apnea Hippocampus Hippocampal formation Amygdala Brain mapping Article 03 medical and health sciences 0302 clinical medicine Seizures Preoperative Care Humans Medicine Prospective Studies Electrocorticography Brain Mapping Neocortex medicine.diagnostic_test business.industry Respiration Human brain Electric Stimulation 030104 developmental biology medicine.anatomical_structure Female Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurology. 88:701-705 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.0000000000003613 |
| Popis: | Objective:To identify limbic sites of respiratory control in the human brain, and by extension, the symptomatogenic zone for central apnea.Methods:We used direct stimulation of anatomically, precisely placed stereotactic EEG electrodes to analyze breathing responses. We prospectively studied 3 patients who were explored with stereotactically implanted depth electrodes. The amygdala and hippocampus, as well as extralimbic sites (orbitofrontal, temporal tip, and temporal neocortex), were investigated.Results:Individual stimulation of the amygdala and hippocampal head consistently elicited central apnea in the expiratory phase, as did exquisitely focal hippocampal seizures.Conclusions:These findings confirm that hippocampus and amygdala are limbic breathing control sites in humans, as well as the symptomatogenic zone for central apneic seizures. |
| Databáze: | OpenAIRE |
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