Diuretics are Similar to Losartan on Echocardiographic Target-Organ Damage in Stage I Hypertension. PREVER-Treatment Study
| Autor: | Carolina Bertoluci, Sandra C. Fuchs, Flávio Danni Fuchs, Angela B. S. Santos, Murilo Foppa |
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| Jazyk: | angličtina |
| Předmět: |
Adult
Male medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system Time Factors Hypertension/therapy Angiotensin-Converting Enzyme Inhibitors Blood Pressure 030204 cardiovascular system & hematology Stage ii Brief Communication Calcium Channel Losartan law.invention Amiloride 03 medical and health sciences Anihypertensive Agents 0302 clinical medicine Hypertension/complications Randomized controlled trial Double-Blind Method law Internal medicine medicine Humans 030212 general & internal medicine Diuretics Antihypertensive Agents Antihypertensive Agents/therapy Aged Ventricular Remodeling business.industry Middle Aged Target organ damage Blood pressure Treatment Outcome Echocardiography lcsh:RC666-701 Treatment study Hypertension Cardiology Chlorthalidone Female Cardiology and Cardiovascular Medicine business medicine.drug Follow-Up Studies |
| Zdroj: | Arquivos Brasileiros de Cardiologia, Vol 112, Iss 1, Pp 87-90 Arquivos Brasileiros de Cardiologia |
| ISSN: | 1678-4170 |
| Popis: | Blood pressure (BP)-lowering therapy improves left ventricular (LV) parameters of hypertensive target-organ damage in stage II hypertension, but whether there is a drug-class difference in echocardiographic parameters in stage I hypertension patients is less often studied. In the PREVER treatment study, where individuals with stage I hypertension were randomized for treatment with diuretics (chlorthalidone/amiloride) or losartan, 110 participants accepted to participate in a sub-study, where two-dimensional echocardiograms were performed at baseline and after 18 months of antihypertensive treatment. As in the general study, systolic BP reduction was similar with diuretics or with losartan. Echocardiographic parameters showed small but significant changes in both treatment groups, with a favorable LV remodeling with antihypertensive treatment for 18 months when target blood pressure was achieved either with chlorthalidone/amiloride or with losartan as the initial treatment strategy. In conclusion, even in stage I hypertension, blood pressure reduction is associated with improvement in echocardiographic parameters, either with diuretics or losartan as first-drug regimens. |
| Databáze: | OpenAIRE |
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