The stimulative function of long noncoding RNA CDKN2B-AS1 in osteosarcoma by targeting the microRNA-122/CCNG1 axis
| Autor: | Abulaiti Abula, Wumitijiang Wuqikun, Peng Ren, Guliayixiamu Saimaiti, Alimujiang Abulaiti, Aihemaitijiang Yusufu, Xayimardan Maimaiti |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cyclin G1 CDKN2B-AS1 Bone Neoplasms Malignancy Biochemistry 03 medical and health sciences 0302 clinical medicine Cell Line Tumor microRNA medicine Humans Diagnostic biomarker Molecular Biology Cell Proliferation Osteosarcoma business.industry Cell Biology medicine.disease Long non-coding RNA Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Cancer research RNA Long Noncoding business Function (biology) |
| Zdroj: | Journal of Receptors and Signal Transduction. 42:71-79 |
| ISSN: | 1532-4281 1079-9893 |
| DOI: | 10.1080/10799893.2020.1850784 |
| Popis: | Osteosarcoma (OS), a prevalent aggressive malignancy in the bone, has limited therapeutic targets and diagnostic biomarkers. In the current investigation, RT-qPCR showed that CDKN2B-AS1 was enhanced in OS samples and cells. This research was set to examine the modulation of CDKN2B-AS1 in OS. The expression of CDKN2B-AS1 and downstream molecules was analyzed by RT-qPCR method. CCK8, EdU staining along with Transwell assays were applied to evaluate cell proliferation and invasion. Those |
| Databáze: | OpenAIRE |
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