The association between serum angiogenin and osteopontin levels and coronary collateral circulation in patients with chronic total occlusion

Autor: Hande Canpinar, Hikmet Yorgun, Duygu Kocyigit, Necla Ozer, Ergun Baris Kaya, Kudret Aytemir, Kadri Murat Gurses, Muhammed Said Beşler, Mehmet Levent Sahiner, Dicle Guc, Lale Tokgozoglu, Banu Evranos, Muhammed Ulvi Yalcin
Přispěvatelé: Selçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Yalçın, Muhammed Ulvi
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
coronary collateral circulation
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty
osteopontin
Angiogenin
Collateral Circulation
Coronary Artery Disease
030204 cardiovascular system & hematology
Coronary Angiography
Coronary artery disease
03 medical and health sciences
Coronary circulation
0302 clinical medicine
Coronary Circulation
Internal medicine
medicine
Humans
Osteopontin
Letter to the Editor
Original Investigation
biology
business.industry
Case-control study
Ribonuclease
Pancreatic
Middle Aged
medicine.disease
Collateral circulation
Coronary arteries
Stenosis
Logistic Models
medicine.anatomical_structure
lcsh:RC666-701
Case-Control Studies
030220 oncology & carcinogenesis
Cardiology
biology.protein
Female
Cardiology and Cardiovascular Medicine
business
angiogenin
Zdroj: Anatolian Journal of Cardiology
Anatolian Journal of Cardiology, Vol 22, Iss 2, Pp 77-84 (2019)
Popis: WOS: 000482646600008
PubMed: 31375653
Objective: A well-developed coronary collateral circulation lowers both in-hospital and long-term morbidity and mortality limiting the infarct. Angiogenin (AGN) and osteopontin (OPN) are known to be potent inducers of angiogenesis. The aim of the present study was to investigate the relationship between serum ANG and OPN levels and collateral filling grade in subjects with stable coronary artery disease (SCAD). Methods: A total of 122 age- and gender-matched consecutive patients who were found to have total occlusion (n=70) and no significant stenosis in epicardial coronary arteries (n=52) who underwent coronary angiography due to SCAD between January 2015 and July 2017 were included in the study. AGN and OPN levels were measured using enzyme-linked immunosorbent assay. Coronary collateral circulation was graded using Rentrop's classification of collateral filling. Results: A total of 52 patients (61.60 +/- 11.78 years, 61.5% male) without significant epicardial coronary artery stenosis and 70 patients (62.87 +/- 8.24 years, 65.7% male) with totally occluded coronary arteries were included in the study. Subjects with total occlusion had significantly higher levels of AGN [122.00 (79.00-623.00) pg/mL vs. 98.00 (18.00-160.00) pg/mL, p
Hacettepe University Scientific Research Projects Coordination UnitHacettepe University [845]
This research was supported by Hacettepe University Scientific Research Projects Coordination Unit (project no.: 845).
Databáze: OpenAIRE
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