Discovery and evaluation of chalcone derivatives as novel potential anti-Toxoplasma gondii agents

Autor:	Liping Jiang, Bo Liu, Shengjie Hou, Tiande Su, Qiyun Fan, Eman Alyafeai, Yaqin Tang, Mengqi Wu, Xiaohua Liu, Jing Li, Yu Hu, Wulan Li, Zhiwei Zheng, Yuan Liu, Jianzhang Wu
Rok vydání:	2022
Předmět:	Pharmacology Mice Chalcone Chalcones Organic Chemistry Drug Discovery Antiprotozoal Agents Animals Aspartate Aminotransferases General Medicine Toxoplasma Toxoplasmosis
Zdroj:	European Journal of Medicinal Chemistry. 234:114244
ISSN:	0223-5234
DOI:	10.1016/j.ejmech.2022.114244
Popis:	Due to numerous side effects of traditional treatments for toxoplasmosis, it is urgent to develop new anti-Toxoplasma agents with high efficiency and low toxicity. In this study, using drug-food-homologous chalcone skeleton as a leading compound, 6 series of chalcone derivatives were designed, synthesized, and almost 1/2 compounds have good anti-Toxoplasma activity in vitro. The quantitative structure-activity relationship model of the anti-Toxoplasma activity of the second batch of compounds was established by random forest method (R
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc14a4de7fab35f324e6a7c9d5aa2dd6 https://doi.org/10.1016/j.ejmech.2022.114244 Zobrazit plný text záznamu Full Text from ScienceDirect