The role of hepatic progenitor cells in predicting response to therapy in Egyptian patients with chronic hepatitis C, genotype 4
| Autor: | Nehal A. Radwan, Naglaa S Ahmed, Thanaa El A Helal, Wahib Aa, Ahmed Me Zaki, Heba Mahmoud, Ahmed M. Aref |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Biopsy 030231 tropical medicine Hepacivirus Chronic hepatitis C Antiviral Agents Gastroenterology Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine response to therapy Fibrosis Pegylated interferon Internal medicine Ribavirin Humans Medicine genotype 4 Progenitor cell hepatic progenitor cells Retrospective Studies business.industry virus diseases Interferon-alpha Articles General Medicine Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease digestive system diseases Liver chemistry Chronic hepatitis C genotype 4 response to therapy hepatic progenitor cells embryonic structures Drug Therapy Combination Egypt Female Steatosis business Viral hepatitis medicine.drug |
| Zdroj: | African Health Sciences; Vol 19, No 1 (2019); 1411-1421 African Health Sciences |
| ISSN: | 1680-6905 |
| Popis: | Background: Interferon therapy is used as a line of treatment of chronic hepatitis C virus (HCV) in several areas of the world including Egypt. Objective: Our aim was to investigate the value of hepatic progenitor cells (HPCs) in predicting response of patients with chronic HCV, genotype 4 to pegylated interferon (PEGIFN) plus ribavirin (RBV) therapy. Methods: Pre-treatment liver biopsies obtained from 110 patients with chronic HCV, genotype 4 were examined immunohisto- chemically for HPCs using cytokeratin19. The mean number of HPCs as ductular reaction (DR) and as isolated progenitor cells (IPCs) was counted in each case. The patients were classified into: those with sustained virological response (SVR) and those who did not achieve SVR. The results were compared between the two groups. Also, the relationships between HPCs and other clinico-pathologic variables were estimated using multivariate analysis. Results: The mean number of HPCs was the only independent predictor of therapeutic response, being significantly higher in non-responders (P = 0 for DR and P = 0.03 for IPCs). On the other hand, fibrosis stage and steatosis were the only independent factors which showed a significant direct association with the mean number of HPCs in the form of DR and IPCs (P = 0 for each). Conclusion: The number of HPCs provides prognostic information in chronic HCV since it is significantly associated with stage of fibrosis. More importantly, it can be used as a marker to predict response of patients with chronic HCV to PEGIFN plus RBV therapy. Keywords: Chronic hepatitis C, genotype 4, response to therapy, hepatic progenitor cells. |
| Databáze: | OpenAIRE |
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