Simultaneous spectrophotometric determination of lamivudine and zidovudine in fixed dose combinations using multivariate calibration
| Autor: | Maria Fernanda Pimentel, Davi Pereira de Santana, Simone S. Simões, Miracy Muniz de Albuquerque, Severino Grangeiro, Reniere H. da Silva |
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| Rok vydání: | 2011 |
| Předmět: |
Chromatography
Chemistry Active components Analytical chemistry Lamivudine Multivariate calibration General Chemistry zidovudine (AZT) Fixed dose High-performance liquid chromatography lcsh:Chemistry Zidovudine Ultraviolet visible spectroscopy lamivudine (3TC) lcsh:QD1-999 Analytical problem multivariate calibration medicine medicine.drug |
| Zdroj: | Química Nova, Vol 34, Iss 5, Pp 859-863 (2011) ResearcherID Química Nova, Volume: 34, Issue: 5, Pages: 859-863, Published: 2011 Química Nova v.34 n.5 2011 Química Nova Sociedade Brasileira de Química (SBQ) instacron:SBQ |
| ISSN: | 0100-4042 |
| DOI: | 10.1590/s0100-40422011000500022 |
| Popis: | The simultaneous determination of two or more active components in pharmaceutical preparations, without previous chemical separation, is a common analytical problem. Published works describe the determination of AZT and 3TC separately, as raw material or in different pharmaceutical preparations. In this work, a method using UV spectroscopy and multivariate calibration is described for the simultaneous measurement of 3TC and AZT in fixed dose combinations. The methodology was validated and applied to determine the AZT+3TC contents in tablets from five different manufacturers, as well as their dissolution profile. The results obtained employing the proposed methodology was similar to methods using first derivative technique and HPLC. |
| Databáze: | OpenAIRE |
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