Evaluation of oral prophylaxis during and after intensity-modulated radiotherapy due to head and neck cancer—a retrospective study
| Autor: | Thomas Attin, Bernd Stadlinger, Dominique Bichsel, K W Grätz, M Lanfranchi |
|---|---|
| Přispěvatelé: | University of Zurich, Bichsel, D |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment 610 Medicine & health Bioinformatics Xerostomia 03 medical and health sciences 0302 clinical medicine 10066 Clinic of Conservative and Preventive Dentistry medicine Humans Head and neck General Dentistry Aged Retrospective Studies Aged 80 and over business.industry Head and neck cancer Radiotherapy Dosage Retrospective cohort study 030206 dentistry Middle Aged medicine.disease 3500 General Dentistry humanities body regions Radiation therapy Head and Neck Neoplasms 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Radiotherapy Intensity-Modulated Intensity modulated radiotherapy Radiology 10069 Clinic of Cranio-Maxillofacial Surgery business Switzerland |
| Zdroj: | Clinical Oral Investigations. 20:721-726 |
| ISSN: | 1436-3771 1432-6981 |
| DOI: | 10.1007/s00784-015-1546-9 |
| Popis: | The aim of this study was to retrospectively analyze the influence of a prophylaxis protocol of head and neck tumor (HNT) patients during and after intensity-modulated radiotherapy (IMRT).In this 5-year retrospective study (2009-2013), 70 (m 55, f 15; age range 28-8 years; median 58.7 years) out of 248 HNT patients of the Clinic of Cranio-Maxillofacial and Oral Surgery at the University of Zurich, Switzerland, fulfilled the inclusion criteria. Parameters of investigation were the salivary flow rates, possible dental foci and the dental status, oral side effects of radiotherapy, the prophylaxis protocol, and patient's compliance to this protocol. The following time points before during and after IMRT (6 weeks) were analyzed: prior to IMRT, 2-4 weeks, 6 weeks and 3, 6, and 12 months after the onset of radiotherapy.Unstimulated salivary flow rate, pH value of unstimulated salivary, and stimulated salivary flow rate showed a significant reduction over time (p0.001). One year after IMRT, both unstimulated and stimulated salivary flow showed a statistically significant lower salivary flow. The number of caries-affected sites per patient was significantly higher for patients with low compliance to the prophylaxis protocol (mean: low compliance 1.36, high compliance 0.26). Almost 75% of the evaluated patients suffered immediate gustatory change, and 47.1% showed signs of radiostomatitis through IMRT.High compliance to the prophylaxis protocol during and after radiotherapy is a key factor for the reduction of radiation side effects on dental hard tissue.High compliance to a monitored prophylaxis program is crucial for patients after head and neck surgery. |
| Databáze: | OpenAIRE |
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