RalA controls glucose homeostasis by regulating glucose uptake in brown fat
| Autor: | Claudia Cordon, Denise E. Lackey, Chao-Wei Hung, Xiao Wei Chen, Yuliya Skorobogatko, Morgan Dragan, Peng Zhao, Martina Wallace, Dan Theodorescu, Christian M. Metallo, Olivia Osborn, Jerrold M. Olefsky, Alan R. Saltiel, Juliane G. Bogner-Strauss, Wenmin Xia, Shannon M. Reilly |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty insulin Glucose uptake medicine.medical_treatment Knockout 1.1 Normal biological development and functioning Ral inhibitors Adipose tissue 03 medical and health sciences Mice Underpinning research Internal medicine 3T3-L1 Cells Brown adipose tissue medicine Adipocytes Glucose homeostasis Homeostasis RaIGAP Animals Insulin Obesity GTPase Metabolic and endocrine Nutrition Multidisciplinary Glucose Transporter Type 4 biology Chemistry GTPase-Activating Proteins Diabetes Glucose transporter Brown Biological Sciences RALA Glut4 RalGAP 030104 developmental biology Endocrinology medicine.anatomical_structure Glucose Adipose Tissue biology.protein ral GTP-Binding Proteins GLUT4 Gene Deletion Signal Transduction |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 30 |
| Popis: | Significance The primary event in diabetes pathogenesis is the development of insulin resistance. Insulin is elevated during feeding and maintains blood glucose levels within a physiological range, largely by increasing glucose uptake in muscle and fat. Our laboratory has identified two components of insulin signaling, the protein RalA and its GAP complex RalGAP, which regulate glucose uptake by fat cells. Using genetic approaches and pharmacological inhibitors, we describe how these proteins influence glucose metabolism in mice. We discovered that RalA is essential for efficient insulin-stimulated glucose uptake in fat, while RalA activation via deletion of RalGAP dramatically increases glucose uptake into brown fat and improves glucose handling in mice (hence, protecting them from developing diabetes). |
| Databáze: | OpenAIRE |
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