Genetic influences on neonatal cortical thickness and surface area
| Autor: | Kai Xia, Dinggang Shen, Jessica B. Girault, Shaili C. Jha, Martin Styner, John H. Gilmore, Hongtu Zhu, Fei Zou, Rebecca C. Knickmeyer, Mihye Ahn, Veronica Murphy, Li Wang, Gang Li, James E. Schmitt |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Heredity Brain development Period (gene) Neuroimaging Biology Article 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Cortex (anatomy) medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Cerebral Cortex Radiological and Ultrasound Technology 05 social sciences Infant Newborn Infant Heritability Magnetic Resonance Imaging Normal variation medicine.anatomical_structure Neurology Evolutionary biology Female Neurology (clinical) Anatomy 030217 neurology & neurosurgery |
| Zdroj: | Human Brain Mapping. 39:4998-5013 |
| ISSN: | 1097-0193 1065-9471 |
| DOI: | 10.1002/hbm.24340 |
| Popis: | Genetic and environmental influences on cortical thickness (CT) and surface area (SA) are thought to vary in a complex and dynamic way across the lifespan. It has been established that CT and SA are genetically distinct in older children, adolescents, and adults, and that heritability varies across cortical regions. Very little however is known about how genetic and environmental factors influence infant CT and SA. Using structural MRI, we performed the first assessment of genetic and environmental influences on normal variation of SA and CT in 360 twin neonates. We observed strong and significant additive genetic influences on total SA (a(2) = 0.78) and small and nonsignificant genetic influences on average CT (a(2) = 0.29). Moreover, we found significant genetic overlap (genetic correlation = 0.65) between these global cortical measures. Regionally, there were minimal genetic influences across the cortex for both CT and SA measures and no distinct patterns of genetic regionalization. Overall, outcomes from this study suggest a dynamic relationship between CT and SA during the neonatal period and provide novel insights into how genetic influences shape cortical structure during early development. |
| Databáze: | OpenAIRE |
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