Genetic feedback for psychiatric conditions: Where are we now and where are we going
Autor: | Sally I.Chun Kuo, Danielle M. Dick, Morgan N. Driver |
---|---|
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Health Knowledge Attitudes Practice Multifactorial Inheritance medicine.medical_specialty Genotype Substance-Related Disorders media_common.quotation_subject Schizophrenia (object-oriented programming) Population 030105 genetics & heredity Article Literacy 03 medical and health sciences Cellular and Molecular Neuroscience Extant taxon medicine Humans Genetic Predisposition to Disease Genetic Testing education Psychiatry Genetics (clinical) Depression (differential diagnoses) Genetic association media_common Depressive Disorder Major education.field_of_study Mental Disorders Genetic architecture Psychiatry and Mental health Mental Health 030104 developmental biology Schizophrenia Substance use Psychology Attitude to Health Genome-Wide Association Study |
Zdroj: | Am J Med Genet B Neuropsychiatr Genet |
ISSN: | 1552-485X 1552-4841 |
Popis: | Genome-wide association studies are rapidly advancing our understanding of the genetic architecture of complex disorders, including many psychiatric conditions such as major depression, schizophrenia, and substance use disorders. One common goal of genome-wide association studies is to use findings for enhanced clinical prediction in the future, which can aid in identifying at-risk individuals to enable more effective prevention screening and treatment strategies. In order to achieve this goal, we first need to gain a better understanding of the issues surrounding the return of complex genetic results. In this article, we summarize the current literature on: (a) genetic literacy in the general population, (b) the public's interest in receiving genetic test results for psychiatric conditions, (c) how individuals react to and interpret their genotypic information for specific psychiatric conditions, and (d) gaps in our knowledge that will be critical to address as we move toward returning genotypic information for psychiatric conditions in both research and clinical settings. By reviewing extant studies, we aim to increase awareness of the potential benefits and consequences of returning genotypic information for psychiatric conditions. |
Databáze: | OpenAIRE |
Externí odkaz: |