Subclinical BCG-osis in a Captive Badger (Meles meles) with Lymphoma

Autor: Sandrine Lesellier, C. Richomme, M.-L. Boschiroli, C. Bianco, A. Núñez, J. Barrat
Přispěvatelé: Animal and Plant Health Agency (APHA), Animal and Plant Health Agency [Weybridge] (APHA), Laboratoire de la rage et de la faune sauvage de Nancy (LRFSN), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé
Rok vydání: 2020
Předmět:
medicine.medical_specialty
Pathology
Lymphoma
Badger
Lymphoid Tissue
040301 veterinary sciences
[SDV]Life Sciences [q-bio]
Bacillus
Meles
Lymphoma
T-Cell
complex mixtures
Mycobacterium
030308 mycology & parasitology
Pathology and Forensic Medicine
0403 veterinary science
03 medical and health sciences
biology.animal
Mustelidae
medicine
Animals
Tuberculosis
Neoplasm
Subclinical infection
0303 health sciences
[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health
General Veterinary
biology
business.industry
Vaccination
Calmette–Guérin
Histology
04 agricultural and veterinary sciences
medicine.disease
biology.organism_classification
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Mycobacterium bovis
3. Good health
BCG Vaccine
Female
Histopathology
business
Zdroj: Journal of Comparative Pathology
Journal of Comparative Pathology, Elsevier, 2020, 176, pp.76-80. ⟨10.1016/j.jcpa.2020.02.009⟩
ISSN: 0021-9975
DOI: 10.1016/j.jcpa.2020.02.009
Popis: International audience; Subclinical systemic dissemination of Bacillus Calmette-Guérin (BCG) is described in a captive badger (Meles meles) with lymphoma. An adult female European badger was vaccinated per os with BCG and after 8 weeks post-mortem examination identified marked lymphadenomegaly and multinodular hepatic lesions. The histopathology and immunohistochemistry confirmed a multicentric T-cell lymphoma, associated with high BCG bacterial load in numerous tissues. The histology did not identify BCG-associated lesions. The scenario suggested that the T-cell lymphoma likely favoured the dissemination of the BCG ('BCG-osis'). Given that lymphoma is rare in badgers, this neoplasm should not interfere with the efficacy of large-scale vaccination programmes.
Databáze: OpenAIRE
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